Details
Title
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
Author
Hudeček, Jan 1
; Voorwerk Leonie 2 ; Maartje, van Seijen 3 ; Nederlof Iris 2 ; de Maaker Michiel 3 ; van den Berg Jose 4 ; van de Vijver Koen K 5
; Sikorska Karolina 6 ; Adams, Sylvia 7 ; Demaria, Sandra 8
; Viale Giuseppe 9 ; Nielsen, Torsten O 10 ; Badve, Sunil S 11
; Michiels, Stefan 12 ; Symmans William Fraser 13
; Sotiriou Christos 14 ; Rimm, David L 15
; Hewitt, Stephen M 16 ; Denkert Carsten 17 ; Loibl Sibylle 18 ; Loi Sherene 19
; Bartlett, John M, S 20 ; Pruneri Giancarlo 21 ; Dillon, Deborah A 22 ; Cheang Maggie C U 23 ; Tutt, Andrew 24 ; Hall, Jacqueline A 25
; Kos Zuzana 26 ; Salgado, Roberto 27 ; Kok Marleen 28 ; Horlings Hugo M 29
; Hyytiäinen Aini 30 ; Hida, Akira I 31 ; Thompson, Alastair 32 ; Lefevre, Alex 33 ; Lazar, Alexander J 34 ; Gown Allen 35 ; Lo, Amy 36 ; Sapino, Anna 37 ; Madabhushi Anant 38 ; Moreira, Andre 39 ; Richardson, Andrea 40 ; Vingiani Andrea 41 ; Beck, Andrew H 42 ; Bellizzi, Andrew M 43 ; Guerrero, Angel 44 ; Grigoriadis, Anita 45 ; Ehinger, Anna 46 ; Garrido-Castro, Ana 47 ; Vincent-Salomon, Anne 48 ; Anne-Vibeke, Laenkholm 49 ; Sharma, Ashish 50 ; Cimino-Mathews, Ashley 51 ; Srinivasan, Ashok 52 ; Acs Balazs 53 ; Singh, Baljit 54 ; Calhoun, Benjamin 55 ; Benjamin, Haibe-Kans 56 ; Solomon, Benjamin 57 ; Thapa Bibhusal 58 ; Nelson, Brad H 59 ; Gallas, Brandon D 60 ; Castaneda, Carlos 61 ; Ballesteros-Merino, Carmen 62 ; Criscitiello, Carmen 63 ; Boeckx Carolien 64 ; Colpaert Cecile 65 ; Quinn, Cecily 66 ; Chennubhotla, Chakra S 67 ; Swanton, Charles 68 ; Solinas Cinzia 69 ; Hiley Crispin 68 ; Drubay Damien 70 ; Bethmann, Daniel 71 ; Moore, David A 72 ; Larsimont Denis 73 ; Dhanusha, Sabanathan 74 ; Peeters Dieter 75 ; Zardavas Dimitrios 76 ; Höflmayer Doris 77 ; Johnson, Douglas B 78 ; Aubrey, Thompson E 79 ; Brogi Edi 80 ; Perez, Edith 81 ; ElGabry, Ehab A 82 ; Specht, Stovgaard Elisabeth 83 ; Blackley, Elizabeth F 57 ; Roblin Elvire 84 ; Reisenbichler Emily 85 ; Bellolio Enrique 86 ; Balslev, Eva 83 ; Chmielik Ewa 87 ; Gaire Fabien 88 ; Andre, Fabrice 89 ; Fang-I, Lu 90 ; Azmoudeh-Ardalan Farid 91 ; Rojo Federico 92 ; Gruosso Tina 93 ; Ciompi Francesco 94 ; Peale Franklin 95 ; Hirsch, Fred R 96 ; Klauschen Frederick 97 ; Penault-Llorca Frédérique 98 ; Acosta, Haab Gabriela 99 ; Gelareh, Farshid 100 ; van den Eynden Gert 101 ; Curigliano Giuseppe 102 ; Floris Giuseppe 103 ; Broeckx Glenn 104 ; Gonzalez-Ericsson 105 ; Koeppen Harmut 36 ; Haynes, Harry R 106 ; McArthur, Heather 107 ; Joensuu Heikki 108 ; Olofsson, Helena 109 ; Huang-Chun, Lien 110 ; I-Chun, Chen 111 ; Cree, Ian 112 ; Frahm, Isabel 113 ; Brcic Iva 114 ; Chan, Jack 115 ; Ziai, James 36 ; Brock, Jane 116 ; Wesseling Jelle 117 ; Giltnane, Jennifer 36 ; Kerner, Jennifer K 118 ; Thagaard Jeppe 119 ; Braybrooke, Jeremy P 120 ; van der Laak Jeroen A W M 121 ; Lemonnier Jerome 122 ; Zha Jiping 123 ; Ribeiro Joana 124 ; Lennerz, Jochen K 125 ; Carter, Jodi M 126 ; Saltz, Joel 127 ; Hartman, Johan 128 ; Hainfellner Johannes 129 ; Quesne John Le 130 ; Juco, Jonathon W 131 ; Reis-Filho, Jorge 132 ; Sanchez Joselyn 133 ; Sparano, Joseph 134 ; Cucherousset Joël 135 ; Araya, Juan Carlos 136 ; Julien, Adam 137 ; Balko, Justin M 138 ; Saeger Kai 139 ; Siziopikou Kalliopi 140 ; Willard-Gallo, Karen 141 ; Weber, Karsten 18 ; Pogue-Geile, Katherine L 142 ; Steele, Keith E 123 ; Emancipator, Kenneth 131 ; AbdulJabbar Khalid 143 ; El Bairi Khalid 144 ; Blenman Kim R M 145 ; Allison, Kimberly H 146 ; Korski Konstanty 147 ; Pusztai Lajos 145 ; Comerma, Laura 148 ; Buisseret Laurence 149 ; Cooper Lee A D 150 ; Shi Leming 151 ; Kooreman, Loes F, S 152 ; Molinero Luciana 153 ; Valeria, Estrada M 154 ; Lacroix-Triki Magali 155 ; Al Bakir Maise 68 ; Sebastian, Manu M 156 ; van de Vijver Marc 157 ; Balancin, Marcelo Luiz 158 ; Dieci, Maria Vittoria 159 ; Mathieu Marie-Christine 160 ; Rebelatto Marlon C 123 ; Piccart Martine 161 ; Hanna, Matthew G 80 ; Goetz, Matthew P 81 ; Preusser Matthias 129 ; Khojasteh Mehrnoush 162 ; Sanders, Melinda E 163 ; Regan, Meredith M 164 ; Barnes, Michael 165 ; Christie, Michael 166 ; Misialek, Michael 167 ; Ignatiadis Michail 168 ; Mieke, van Bockstal 169 ; Castillo Miluska 170 ; Mohamed, Amgad 171 ; Harbeck Nadia 172 ; Tung, Nadine 173 ; Laudus Nele 174 ; Sirtaine Nicolas 175 ; Burchardi, Nicole 18 ; Ternes Nils 176 ; Radosevic-Robin Nina 177 ; Gluz Oleg 178 ; Grimm, Oliver 88 ; Nuciforo Paolo 179 ; Jank, Paul 180 ; Gonzalez-Ericsson, Paula 181 ; Kirtani Pawan 182 ; Jelinic Petar 131 ; Watson, Peter H 183 ; Savas, Peter 184 ; Francis, Prudence A 185 ; Russell, Prudence A 186 ; Singh, Rajendra 187 ; Kim, Rim S 188 ; Pierce, Robert H 189 ; Hills, Robert 190 ; Leon-Ferre, Roberto 81 ; de Wind Roland 191 ; Shui Ruohong 192 ; Sabine, De Clercq 193 ; Leung, Sam 194 ; Tabbarah Sami 195 ; Souza, Sandra C 196 ; O’Toole Sandra 197 ; Swain, Sandra 198 ; Dudgeon, Sarah 199 ; Willis Scooter 200 ; Ely, Scott 201 ; Seong-Rim, Kim 52 ; Bedri Shahinaz 202 ; Irshad Sheeba 203 ; Shi-Wei, Liu 204 ; Goel Shom 185 ; Hendry Shona 205 ; Bianchi Simonetta 206 ; Bragança Sofia 207 ; Paik Soonmyung 52 ; Wienert Stephan 208 ; Fox, Stephen B 205 ; Luen, Stephen J 19 ; Naber, Stephen 209 ; Schnitt, Stuart J 210 ; Sua Luz F 211 ; Lakhani, Sunil R 212 ; Fineberg, Susan 213 ; Soler, Teresa 214 ; Gevaert, Thomas 215 ; D’Alfonso Timothy 80 ; Tom, John 216 ; Tomohagu, Sugie 217 ; Kurkure Uday 218 ; Bossuyt Veerle 125 ; Manem Venkata 219 ; Cámara, Vincente Peg 220 ; Weida, Tong 221 ; Chen, Weijie 60 ; Yang, Wentao 192 ; Tran, William T 195 ; Wang, Yihong 222 ; Yuan Yinyin 143 ; Allory Yves 223 ; Husain Zaheed 224 ; Bago-Horvath Zsuzsanna 225
1 The Netherlands Cancer Institute, Department of Research IT, Amsterdam, The Netherlands (GRID:grid.430814.a)
2 The Netherlands Cancer Institute, Division of Tumor Biology and Immunology, Amsterdam, The Netherlands (GRID:grid.430814.a)
3 The Netherlands Cancer Institute, Division of Molecular Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
4 The Netherlands Cancer Institute, Department of Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
5 Ghent University Hospital, Department of Pathology, Ghent, Belgium (GRID:grid.410566.0) (ISNI:0000 0004 0626 3303)
6 The Netherlands Cancer Institute, Department of Biometrics, Amsterdam, The Netherlands (GRID:grid.430814.a)
7 New York University School of Medicine, Department of Medicine, Perlmutter Cancer Center, New York, USA (GRID:grid.137628.9) (ISNI:0000 0004 1936 8753)
8 Weill Cornell Medicine, Department of Radiation Oncology, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X); Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X)
9 IEO European Institute of Oncology IRCCS, International Breast Cancer Study Group Central Pathology Office, Department of Pathology and Laboratory Medicine, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843); University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
10 University of British Columbia, Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
11 Indiana University Simon Cancer Center, Department of Pathology and Laboratory Medicine, Indianapolis, USA (GRID:grid.257413.6) (ISNI:0000 0001 2287 3919)
12 Université Paris-Saclay, Service de Biostatistique et d’Epidémiologie, Gustave Roussy, CESP, Université-Paris Sud, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535); Université Paris-Saclay, CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535)
13 M.D. Anderson Cancer Center, Department of Pathology, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
14 Université Libre de Bruxelles, Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Brussels, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 0746)
15 Yale School of Medicine, Department of Pathology, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710); Yale University School of Medicine, Department of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
16 National Cancer Institute, Laboratory of Pathology, Center for Cancer Research, Bethesda, USA (GRID:grid.48336.3a) (ISNI:0000 0004 1936 8075)
17 Charité Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662); Philipps-University Marburg, Institute of Pathology, Marburg, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756)
18 German Breast Group, Neu-Isenburg, Germany (GRID:grid.434440.3) (ISNI:0000 0004 0457 2954)
19 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
20 Ontario Institute for Cancer Research, Toronto, Canada (GRID:grid.419890.d) (ISNI:0000 0004 0626 690X); IGMM, Edinburgh, UK (GRID:grid.415854.9) (ISNI:0000 0004 0605 7892); Western General Hospital, Edinburgh Cancer Research Centre, Edinburgh, UK (GRID:grid.417068.c) (ISNI:0000 0004 0624 9907)
21 IRCCS Fondazion - Instituto Nazionale Tumori, Department of Pathology and Laboratory Medicine, Milan, Italy (GRID:grid.417893.0) (ISNI:0000 0001 0807 2568); University of Milan, School of Medicine, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
22 Harvard Medical School, Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
23 The Institute of Cancer Research, Clinical Trials and Statistics Unit, Surrey, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
24 The Institute of Cancer Research, Breast Cancer Now Toby Robins Research Centre, London, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
25 Vivactiv Ltd, Research and Development, Chesham, UK (GRID:grid.18886.3f)
26 University of Ottawa, Department of Pathology and Laboratory Medicine, Ottawa, Canada (GRID:grid.28046.38) (ISNI:0000 0001 2182 2255)
27 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); GZA-ZNA Ziekenhuizen, Department of Pathology, Antwerp, Belgium (GRID:grid.428965.4) (ISNI:0000 0004 7536 2436)
28 The Netherlands Cancer Institute, Division of Tumor Biology and Immunology, Amsterdam, The Netherlands (GRID:grid.430814.a); The Netherlands Cancer Institute, Department of Medical Oncology, Amsterdam, The Netherlands (GRID:grid.430814.a)
29 The Netherlands Cancer Institute, Division of Molecular Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a); The Netherlands Cancer Institute, Department of Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
30 Department of Oral and Maxillofacial Diseases, Helsinki, Finland (GRID:grid.430814.a)
31 Department of Pathology, Matsuyama Shimin Hospital, Matsuyama, Japan (GRID:grid.459780.7) (ISNI:0000 0004 1772 4320)
32 Surgical Oncology, Baylor College of Medicine, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X)
33 Roche Diagnostics, Mechelen, Belgium (GRID:grid.39382.33)
34 Departments of Pathology, Genomic Medicine, Dermatology, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
35 PhenoPath Laboratories, Seattle, USA (GRID:grid.240145.6)
36 Research Pathology, Genentech Inc., South San Francisco, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
37 University of Turin/Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy (GRID:grid.7605.4) (ISNI:0000 0001 2336 6580)
38 Case Western Reserve University, Cleveland, USA (GRID:grid.67105.35) (ISNI:0000 0001 2164 3847); Louis Stokes Cleveland Veterans Health Administration Medical Center, Cleveland, USA (GRID:grid.67105.35)
39 Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, USA (GRID:grid.137628.9) (ISNI:0000 0004 1936 8753)
40 Department of Pathology, Johns Hopkins Hospital, Baltimore, USA (GRID:grid.411935.b) (ISNI:0000 0001 2192 2723)
41 Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
42 PathAI, Inc, Cambridge, USA (GRID:grid.479429.5)
43 Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, USA (GRID:grid.412584.e) (ISNI:0000 0004 0434 9816)
44 Department of Oncology, IVO, Valencia, Spain (GRID:grid.418082.7) (ISNI:0000 0004 1771 144X)
45 Cancer Bioinformatics Lab, Cancer Centre at Guy’s Hospital, London, UK (GRID:grid.239826.4) (ISNI:0000 0004 0391 895X); School of Life Sciences and Medicine, King’s College London, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
46 Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Oncology and Pathology, Lund, Sweden (GRID:grid.13097.3c)
47 Dana Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910)
48 Institut Curie, Paris Sciences Lettres Université, Inserm U934, Department of Pathology, Paris, France (GRID:grid.65499.37)
49 Department of Surgical Pathology, Zealand University Hospital, Køge, Denmark (GRID:grid.476266.7)
50 Department of Biomedical Informatics, Emory University, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502)
51 Departments of Pathology and Oncology, The Johns Hopkins Hospital, Baltimore, USA (GRID:grid.411935.b) (ISNI:0000 0001 2192 2723)
52 National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
53 Department of Pathology, Karolinska Institutet, Karolinska, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626)
54 Department of Pathology, New York University Langone Medical Centre, New York, USA (GRID:grid.4714.6)
55 Department of Pathology and Laboratory Medicine, UNC School of Medicine, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208)
56 Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, Toronto, Canada (GRID:grid.10698.36)
57 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434)
58 Department of Medicine, University of Melbourne, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
59 Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, Canada (GRID:grid.248762.d) (ISNI:0000 0001 0702 3000)
60 Division of Imaging, Diagnostics, and Software Reliability (DIDSR), Office of Science and Engineering Laboratories (OSEL), Center for Devices and Radiological Health (CDRH), Rockville, USA (GRID:grid.413579.d) (ISNI:0000 0001 2285 9893)
61 Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024); Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
62 Providence Cancer Research Center, Portland, Oregon, USA (GRID:grid.419177.d)
63 Department of Medical Oncology, Istituto Europeo di Oncologia, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843)
64 Roche Diagnostics, Mechelen, Belgium (GRID:grid.15667.33)
65 Department of Pathology, AZ Turnhout, Turnhout, Belgium (GRID:grid.476094.8)
66 Department of Pathology, St Vincent’s University Hospital and University College Dublin, Dublin, Ireland (GRID:grid.7886.1) (ISNI:0000 0001 0768 2743)
67 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
68 Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
69 Azienda AUSL, Regional Hospital of Aosta, Aosta, Italy (GRID:grid.83440.3b)
70 Université Paris-Sud, Institut National de la Santé et de la Recherche Médicale, Villejuif, France (GRID:grid.5842.b) (ISNI:0000 0001 2171 2558); Gustave Roussy, Universite Paris-Saclay, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
71 University Hospital Halle (Saale), Institute of Pathology, Halle, Germany (GRID:grid.461820.9) (ISNI:0000 0004 0390 1701)
72 Department of Pathology, UCL Cancer Institute, UCL, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201); University College Hospitals NHS Trust, London, UK (GRID:grid.52996.31) (ISNI:0000 0000 8937 2257)
73 Department of Pathology, Jules Bordet Institute, Brussels, Belgium (GRID:grid.418119.4) (ISNI:0000 0001 0684 291X)
74 Department of Clinical Medicine, Macquarie University, Sydney, Australia (GRID:grid.1004.5) (ISNI:0000 0001 2158 5405)
75 HistoGeneX NV, Antwerp, Belgium and AZ Sint-Maarten Hospital, Mechelen, Belgium (GRID:grid.1004.5)
76 Oncology Clinical Development, Bristol-Myers Squibb, Princeton, USA (GRID:grid.419971.3)
77 Institut für Pathologie, UK Hamburg, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
78 Department of Medicine, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
79 Department of Cancer CV, Jacksonville, USA (GRID:grid.412807.8)
80 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
81 Department of Oncology, Mayo Clinic, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
82 Roche, Tucson, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
83 Department of Pathology, Herlev and Gentofte Hospital, Gentofte, Denmark (GRID:grid.411646.0) (ISNI:0000 0004 0646 7402)
84 Université Paris-Saclay, Univ. Paris-Sud, Villejuif, France (GRID:grid.5842.b) (ISNI:0000 0001 2171 2558); Service de biostatistique et d’épidémiologie, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
85 Yale School of Medicine, Department of Pathology, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
86 Department of Pathology, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552); Departamento de Anatomía Patológica, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552)
87 Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center, Gliwice, Poland (GRID:grid.418165.f) (ISNI:0000 0004 0540 2543)
88 Pathology and Tissue Analytics, Roche, Neuherberg, Germany (GRID:grid.424277.0)
89 Department of Medical Oncology, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
90 Sunnybrook Health Sciences Centre, Toronto, Canada (GRID:grid.413104.3) (ISNI:0000 0000 9743 1587)
91 Tehran University of Medical Sciences, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
92 Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain (GRID:grid.5515.4) (ISNI:0000000119578126); GEICAM-Spanish Breast Cancer Research Group, Madrid, Spain (GRID:grid.430580.a)
93 Translational Research, Montreal, Canada (GRID:grid.430580.a)
94 Computational Pathology Group, Department of Pathology, Nijmegen, The Netherlands (GRID:grid.430580.a)
95 Oncology Biomarker Development, Genentech-Roche, Neuherberg, Germany (GRID:grid.430580.a)
96 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA (GRID:grid.430503.1) (ISNI:0000 0001 0703 675X)
97 Charité Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662)
98 Centre de Lutte Contre le cancer - Centre Jean Perrin, Clermont-Ferrand, France (GRID:grid.418113.e) (ISNI:0000 0004 1795 1689)
99 Department of Pathology, Hospital de Oncología Maria Curie, Buenos Aires, Argentina (GRID:grid.418113.e)
100 Directorate of Surgical Pathology, SA Pathology, Adelaide, Australia (GRID:grid.414733.6) (ISNI:0000 0001 2294 430X)
101 Department of Pathology, GZA-ZNA Ziekenhuizen, Wilrijk, Belgium (GRID:grid.414733.6)
102 University of Milano, Instituto Europeo di Oncologia, IRCCS, Milano, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822); Division of Early Drug Development for Innovative Therapy, IEO, European Institute of Oncology IRCCS, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843)
103 Department of Imaging and Pathology, Laboratory of TranslCal Cell & Tissue Research, Leuven, Belgium (GRID:grid.15667.33); KU Leuven- University Hospitals Leuven, Department of Pathology, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
104 Department of Pathology, University Hospital of Antwerp, Antwerp, Belgium (GRID:grid.411414.5) (ISNI:0000 0004 0626 3418)
105 Paula I, Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
106 Translational Health Sciences, Department of Cellular Pathology, North Bristol NHS Trust, University of Bristol, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603)
107 Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA (GRID:grid.50956.3f) (ISNI:0000 0001 2152 9905)
108 Helsinki University Central Hospital, Helsinki, Finland (GRID:grid.15485.3d) (ISNI:0000 0000 9950 5666)
109 Department of Clinical Pathology, Akademiska University Hospital, Uppsala, Sweden (GRID:grid.412354.5) (ISNI:0000 0001 2351 3333)
110 Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan (GRID:grid.412094.a) (ISNI:0000 0004 0572 7815)
111 Department of Oncology, National Taiwan University Cancer Center, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241)
112 International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (GRID:grid.17703.32) (ISNI:0000000405980095)
113 Department of Pathology, Sanatorio Mater Dei, Buenos Aires, Argentina (GRID:grid.17703.32)
114 Institute of Pathology, Medical University of Graz, Graz, Austria (GRID:grid.11598.34) (ISNI:0000 0000 8988 2476)
115 Department of Oncology, National Cancer Centre Singapore, Singapore, Singapore (GRID:grid.410724.4) (ISNI:0000 0004 0620 9745)
116 Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294)
117 Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands (GRID:grid.430814.a)
118 PathAI Inc, Cambridge, USA (GRID:grid.479429.5)
119 Visiopharm A/S, Hørsholm, Denmark (GRID:grid.479429.5); DTU Compute, Department of Applied Mathematics, Technical University of Denmark, Lyngby, Denmark (GRID:grid.5170.3) (ISNI:0000 0001 2181 8870)
120 Nuffield Department of Population Health, University of Oxford, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948); Department of Medical Oncology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK (GRID:grid.410421.2) (ISNI:0000 0004 0380 7336)
121 Computational Pathology Group, Department of Pathology, Nijmegen, The Netherlands (GRID:grid.410421.2)
122 R&D UNICANCER, Paris, France (GRID:grid.410421.2)
123 Translational Sciences, MedImmune, Gaithersberg, USA (GRID:grid.418152.b)
124 Breast Unit, Champalimaud Clinical Centre, Lisboa, Portugal (GRID:grid.418152.b)
125 Department of Pathology, Massachusetts General Hospital, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924)
126 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
127 Biomedical Informatics Department, Stony Brook University, Stony Brook, USA (GRID:grid.36425.36) (ISNI:0000 0001 2216 9681)
128 Department of Oncology and Pathology, Karolinska Institutet and University Hospital, Solna, Sweden (GRID:grid.24381.3c) (ISNI:0000 0000 9241 5705)
129 Department of Medicine, Clinical Division of Oncology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)
130 Leicester Cancer Research Centre, University of Leicester, Leicester, and MRC Toxicology Unit, University of Cambridge, Cambridge, UK (GRID:grid.5335.0) (ISNI:0000000121885934)
131 Merck & Co., Inc, Kenilworth, USA (GRID:grid.417993.1) (ISNI:0000 0001 2260 0793)
132 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952); Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
133 Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
134 Department of Medicine, Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein Medical Center, Bronx, USA (GRID:grid.419177.d)
135 GHI Le Raincy-Montfermeil, Chelles, Île-de-France, France (GRID:grid.420138.c) (ISNI:0000 0000 8620 9964)
136 Department of Pathology, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552)
137 Department of Pathology, Gustave Roussy, Grand Paris, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
138 Departments of Medicine and Cancer Biology, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
139 VMscope GmbH, Berlin, Germany (GRID:grid.412807.8)
140 Department of Pathology, Breast Pathology Section, Northwestern University, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)
141 Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.16753.36)
142 NSABP/NRG Oncology, Pittsburgh, USA (GRID:grid.434440.3)
143 Division of Molecular Pathology, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
144 Cancer Biomarkers Working Group, Faculty of Medicine and Pharmacy, Université Mohamed Premier, Oujda, Morocco (GRID:grid.410890.4) (ISNI:0000 0004 1772 8348)
145 Yale Cancer Center Genetics, Genomics and Epigenetics Program, Yale School of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
146 Pathology Department, Stanford University Medical Centre, Stanford, USA (GRID:grid.47100.32)
147 Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg, Germany (GRID:grid.47100.32)
148 Pathology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811); GEICAM-Spanish Breast Cancer Research Group, Madrid, Spain (GRID:grid.430580.a)
149 Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.430580.a)
150 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)
151 Center for Pharmacogenomics and Fudan-Zhangjiang, Center for Clinical Genomics School of Life Sciences and Shanghai Cancer Center, Fudan University, Fudan, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443)
152 GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre and Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands (GRID:grid.412966.e) (ISNI:0000 0004 0480 1382)
153 Oncology Biomarker Development, Genentech-Roche, Neuherberg, Germany (GRID:grid.412966.e)
154 Biorepository and Tissue Technology Shared Resources, University of California San Diego, San Diego, USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)
155 Department of Pathology, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
156 Departments of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
157 Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
158 Department of Pathology, University of São Paulo, São Paulo, Brazil (GRID:grid.11899.38) (ISNI:0000 0004 1937 0722); Hospital das Clínicas, Sao Paulo, Brasil (GRID:grid.411074.7) (ISNI:0000 0001 2297 2036)
159 Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470)
160 Department of Medical Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
161 Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium (GRID:grid.418119.4) (ISNI:0000 0001 0684 291X)
162 Roche Tissue Diagnostics, Digital Pathology, Santa Clara, USA (GRID:grid.22937.3d)
163 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
164 Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
165 Roche Diagnostics Information Solutions, Belmont, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
166 Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Australia (GRID:grid.416153.4) (ISNI:0000 0004 0624 1200)
167 Vernon Cancer Center, Newton-Wellesley Hospital, Newton, USA (GRID:grid.416176.3) (ISNI:0000 0000 9957 1751)
168 Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.416176.3)
169 Service de pathologique, Cliniques universitaires Saint-Luc, Bruxelles, Belgique (GRID:grid.48769.34) (ISNI:0000 0004 0461 6320)
170 Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
171 Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502)
172 Breast Center, Dept. OB&GYN and CCC (LMU), University of Munich, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
173 Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, USA (GRID:grid.239395.7) (ISNI:0000 0000 9011 8547)
174 University of Leuven, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
175 Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.5596.f)
176 Université Paris-Saclay, Service de Biostatistique et d’Epidémiologie, Gustave Roussy, CESP, Université-Paris Sud, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535)
177 Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France (GRID:grid.460789.4)
178 Johanniter GmbH - Evangelisches Krankenhaus Bethesda Mönchengladbach, West German Study Group, Mönchengladbach, Germany (GRID:grid.476830.e)
179 Molecular Oncology Group, Vall d’Hebron Institute of Oncology, Barcelona, Spain (GRID:grid.411083.f) (ISNI:0000 0001 0675 8654)
180 Department of Pathology, University of Marburg, Marburg, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756)
181 Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
182 Department of Histopathology, Manipal Hospitals Dwarka, New Delhi, India (GRID:grid.412807.8)
183 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
184 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
185 Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
186 Department of Anatomical Pathology, St Vincent’s Hospital Melbourne, Fitzroy, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560)
187 Icahn School of Medicine at Mt. Sinai, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351)
188 NRG Oncology/NSABP, Pittsburgh, USA (GRID:grid.59734.3c)
189 Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, USA (GRID:grid.270240.3) (ISNI:0000 0001 2180 1622)
190 Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
191 Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.66875.3a)
192 Department of Pathology, Fudan University Cancer Center, Shanghai, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443)
193 Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium (GRID:grid.428965.4) (ISNI:0000 0004 7536 2436)
194 University of British Columbia, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
195 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Research Institute, Toronto, Canada (GRID:grid.17063.33) (ISNI:0000 0001 2157 2938)
196 Merck Oncology, Kenilworth, USA (GRID:grid.17063.33)
197 The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia (GRID:grid.415306.5) (ISNI:0000 0000 9983 6924)
198 Georgetown University Medical Center, Washington, USA (GRID:grid.411667.3) (ISNI:0000 0001 2186 0438)
199 FDA/CDRH/OSEL/Division of Imaging, Diagnostics, and Software Reliability, Silver Spring, USA (GRID:grid.411667.3)
200 Department of Molecular and Experimental Medicine, Avera Cancer Institute, Sioux Falls, USA (GRID:grid.414118.9) (ISNI:0000 0004 0464 4831)
201 Translational Medicine, Bristol-Myers Squibb, Princeton, USA (GRID:grid.419971.3)
202 Anatomic Pathology, Boston, USA (GRID:grid.21925.3d)
203 Guy’s Hospital, London, UK (GRID:grid.239826.4) (ISNI:0000 0004 0391 895X); King’s College London, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
204 Peking University First Hospital Breast Disease Center, Beijing, China (GRID:grid.411472.5) (ISNI:0000 0004 1764 1621)
205 Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434)
206 Dipartimento di Scienze della Salute (DSS), Firenze, Italy (GRID:grid.1055.1)
207 Department of Oncology, Champalimaud Clinical Centre, Lisbon, Portugal (GRID:grid.1055.1)
208 Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Berlin, Germany (GRID:grid.21925.3d)
209 Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045)
210 Harvard Medical School, Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Dana-Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910)
211 Department of Pathology, Fundación Valle del Lili, Cali, Valle del Cauca, Colombia (GRID:grid.477264.4)
212 The University of Queensland Centre for Clinical Research and Pathology Queensland, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537)
213 Department of Pathology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, USA (GRID:grid.240283.f) (ISNI:0000 0001 2152 0791)
214 Department of Pathology, University Hospital of Bellvitge, Oncobell, IDIBELL, L’Hospitalet del Llobregat, Barcelona, Spain (GRID:grid.240283.f)
215 Department of Development and Regeneration, Laboratory of Experimental Urology, KU Leuven, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
216 Department of Medical Oncology, Austin Health, Heidelberg, Australia (GRID:grid.410678.c)
217 Department of Surgery, Kansai Medical School, Hirakata, Japan (GRID:grid.410783.9) (ISNI:0000 0001 2172 5041)
218 Roche Tissue Diagnostics, Digital Pathology, Santa Clara, USA (GRID:grid.410783.9)
219 Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, Toronto, Canada (GRID:grid.32224.35)
220 Pathology Department, H.U. Vall d’Hebron, Barcelona, Spain (GRID:grid.32224.35)
221 Division of Bioinformatics and Biostatistics, US Food and Drug Administration, Silver Spring, USA (GRID:grid.417587.8) (ISNI:0000 0001 2243 3366)
222 Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Providence, USA (GRID:grid.17063.33)
223 Université Paris-Est, Créteil, France (GRID:grid.410511.0) (ISNI:0000 0001 2149 7878)
224 Praava Health, Dhaka, Bangladesh (GRID:grid.410511.0)
225 Department of Pathology, Medical University of Vienna, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)
; Voorwerk Leonie 2 ; Maartje, van Seijen 3 ; Nederlof Iris 2 ; de Maaker Michiel 3 ; van den Berg Jose 4 ; van de Vijver Koen K 5
; Sikorska Karolina 6 ; Adams, Sylvia 7 ; Demaria, Sandra 8
; Viale Giuseppe 9 ; Nielsen, Torsten O 10 ; Badve, Sunil S 11
; Michiels, Stefan 12 ; Symmans William Fraser 13
; Sotiriou Christos 14 ; Rimm, David L 15
; Hewitt, Stephen M 16 ; Denkert Carsten 17 ; Loibl Sibylle 18 ; Loi Sherene 19
; Bartlett, John M, S 20 ; Pruneri Giancarlo 21 ; Dillon, Deborah A 22 ; Cheang Maggie C U 23 ; Tutt, Andrew 24 ; Hall, Jacqueline A 25
; Kos Zuzana 26 ; Salgado, Roberto 27 ; Kok Marleen 28 ; Horlings Hugo M 29
; Hyytiäinen Aini 30 ; Hida, Akira I 31 ; Thompson, Alastair 32 ; Lefevre, Alex 33 ; Lazar, Alexander J 34 ; Gown Allen 35 ; Lo, Amy 36 ; Sapino, Anna 37 ; Madabhushi Anant 38 ; Moreira, Andre 39 ; Richardson, Andrea 40 ; Vingiani Andrea 41 ; Beck, Andrew H 42 ; Bellizzi, Andrew M 43 ; Guerrero, Angel 44 ; Grigoriadis, Anita 45 ; Ehinger, Anna 46 ; Garrido-Castro, Ana 47 ; Vincent-Salomon, Anne 48 ; Anne-Vibeke, Laenkholm 49 ; Sharma, Ashish 50 ; Cimino-Mathews, Ashley 51 ; Srinivasan, Ashok 52 ; Acs Balazs 53 ; Singh, Baljit 54 ; Calhoun, Benjamin 55 ; Benjamin, Haibe-Kans 56 ; Solomon, Benjamin 57 ; Thapa Bibhusal 58 ; Nelson, Brad H 59 ; Gallas, Brandon D 60 ; Castaneda, Carlos 61 ; Ballesteros-Merino, Carmen 62 ; Criscitiello, Carmen 63 ; Boeckx Carolien 64 ; Colpaert Cecile 65 ; Quinn, Cecily 66 ; Chennubhotla, Chakra S 67 ; Swanton, Charles 68 ; Solinas Cinzia 69 ; Hiley Crispin 68 ; Drubay Damien 70 ; Bethmann, Daniel 71 ; Moore, David A 72 ; Larsimont Denis 73 ; Dhanusha, Sabanathan 74 ; Peeters Dieter 75 ; Zardavas Dimitrios 76 ; Höflmayer Doris 77 ; Johnson, Douglas B 78 ; Aubrey, Thompson E 79 ; Brogi Edi 80 ; Perez, Edith 81 ; ElGabry, Ehab A 82 ; Specht, Stovgaard Elisabeth 83 ; Blackley, Elizabeth F 57 ; Roblin Elvire 84 ; Reisenbichler Emily 85 ; Bellolio Enrique 86 ; Balslev, Eva 83 ; Chmielik Ewa 87 ; Gaire Fabien 88 ; Andre, Fabrice 89 ; Fang-I, Lu 90 ; Azmoudeh-Ardalan Farid 91 ; Rojo Federico 92 ; Gruosso Tina 93 ; Ciompi Francesco 94 ; Peale Franklin 95 ; Hirsch, Fred R 96 ; Klauschen Frederick 97 ; Penault-Llorca Frédérique 98 ; Acosta, Haab Gabriela 99 ; Gelareh, Farshid 100 ; van den Eynden Gert 101 ; Curigliano Giuseppe 102 ; Floris Giuseppe 103 ; Broeckx Glenn 104 ; Gonzalez-Ericsson 105 ; Koeppen Harmut 36 ; Haynes, Harry R 106 ; McArthur, Heather 107 ; Joensuu Heikki 108 ; Olofsson, Helena 109 ; Huang-Chun, Lien 110 ; I-Chun, Chen 111 ; Cree, Ian 112 ; Frahm, Isabel 113 ; Brcic Iva 114 ; Chan, Jack 115 ; Ziai, James 36 ; Brock, Jane 116 ; Wesseling Jelle 117 ; Giltnane, Jennifer 36 ; Kerner, Jennifer K 118 ; Thagaard Jeppe 119 ; Braybrooke, Jeremy P 120 ; van der Laak Jeroen A W M 121 ; Lemonnier Jerome 122 ; Zha Jiping 123 ; Ribeiro Joana 124 ; Lennerz, Jochen K 125 ; Carter, Jodi M 126 ; Saltz, Joel 127 ; Hartman, Johan 128 ; Hainfellner Johannes 129 ; Quesne John Le 130 ; Juco, Jonathon W 131 ; Reis-Filho, Jorge 132 ; Sanchez Joselyn 133 ; Sparano, Joseph 134 ; Cucherousset Joël 135 ; Araya, Juan Carlos 136 ; Julien, Adam 137 ; Balko, Justin M 138 ; Saeger Kai 139 ; Siziopikou Kalliopi 140 ; Willard-Gallo, Karen 141 ; Weber, Karsten 18 ; Pogue-Geile, Katherine L 142 ; Steele, Keith E 123 ; Emancipator, Kenneth 131 ; AbdulJabbar Khalid 143 ; El Bairi Khalid 144 ; Blenman Kim R M 145 ; Allison, Kimberly H 146 ; Korski Konstanty 147 ; Pusztai Lajos 145 ; Comerma, Laura 148 ; Buisseret Laurence 149 ; Cooper Lee A D 150 ; Shi Leming 151 ; Kooreman, Loes F, S 152 ; Molinero Luciana 153 ; Valeria, Estrada M 154 ; Lacroix-Triki Magali 155 ; Al Bakir Maise 68 ; Sebastian, Manu M 156 ; van de Vijver Marc 157 ; Balancin, Marcelo Luiz 158 ; Dieci, Maria Vittoria 159 ; Mathieu Marie-Christine 160 ; Rebelatto Marlon C 123 ; Piccart Martine 161 ; Hanna, Matthew G 80 ; Goetz, Matthew P 81 ; Preusser Matthias 129 ; Khojasteh Mehrnoush 162 ; Sanders, Melinda E 163 ; Regan, Meredith M 164 ; Barnes, Michael 165 ; Christie, Michael 166 ; Misialek, Michael 167 ; Ignatiadis Michail 168 ; Mieke, van Bockstal 169 ; Castillo Miluska 170 ; Mohamed, Amgad 171 ; Harbeck Nadia 172 ; Tung, Nadine 173 ; Laudus Nele 174 ; Sirtaine Nicolas 175 ; Burchardi, Nicole 18 ; Ternes Nils 176 ; Radosevic-Robin Nina 177 ; Gluz Oleg 178 ; Grimm, Oliver 88 ; Nuciforo Paolo 179 ; Jank, Paul 180 ; Gonzalez-Ericsson, Paula 181 ; Kirtani Pawan 182 ; Jelinic Petar 131 ; Watson, Peter H 183 ; Savas, Peter 184 ; Francis, Prudence A 185 ; Russell, Prudence A 186 ; Singh, Rajendra 187 ; Kim, Rim S 188 ; Pierce, Robert H 189 ; Hills, Robert 190 ; Leon-Ferre, Roberto 81 ; de Wind Roland 191 ; Shui Ruohong 192 ; Sabine, De Clercq 193 ; Leung, Sam 194 ; Tabbarah Sami 195 ; Souza, Sandra C 196 ; O’Toole Sandra 197 ; Swain, Sandra 198 ; Dudgeon, Sarah 199 ; Willis Scooter 200 ; Ely, Scott 201 ; Seong-Rim, Kim 52 ; Bedri Shahinaz 202 ; Irshad Sheeba 203 ; Shi-Wei, Liu 204 ; Goel Shom 185 ; Hendry Shona 205 ; Bianchi Simonetta 206 ; Bragança Sofia 207 ; Paik Soonmyung 52 ; Wienert Stephan 208 ; Fox, Stephen B 205 ; Luen, Stephen J 19 ; Naber, Stephen 209 ; Schnitt, Stuart J 210 ; Sua Luz F 211 ; Lakhani, Sunil R 212 ; Fineberg, Susan 213 ; Soler, Teresa 214 ; Gevaert, Thomas 215 ; D’Alfonso Timothy 80 ; Tom, John 216 ; Tomohagu, Sugie 217 ; Kurkure Uday 218 ; Bossuyt Veerle 125 ; Manem Venkata 219 ; Cámara, Vincente Peg 220 ; Weida, Tong 221 ; Chen, Weijie 60 ; Yang, Wentao 192 ; Tran, William T 195 ; Wang, Yihong 222 ; Yuan Yinyin 143 ; Allory Yves 223 ; Husain Zaheed 224 ; Bago-Horvath Zsuzsanna 225 1 The Netherlands Cancer Institute, Department of Research IT, Amsterdam, The Netherlands (GRID:grid.430814.a)
2 The Netherlands Cancer Institute, Division of Tumor Biology and Immunology, Amsterdam, The Netherlands (GRID:grid.430814.a)
3 The Netherlands Cancer Institute, Division of Molecular Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
4 The Netherlands Cancer Institute, Department of Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
5 Ghent University Hospital, Department of Pathology, Ghent, Belgium (GRID:grid.410566.0) (ISNI:0000 0004 0626 3303)
6 The Netherlands Cancer Institute, Department of Biometrics, Amsterdam, The Netherlands (GRID:grid.430814.a)
7 New York University School of Medicine, Department of Medicine, Perlmutter Cancer Center, New York, USA (GRID:grid.137628.9) (ISNI:0000 0004 1936 8753)
8 Weill Cornell Medicine, Department of Radiation Oncology, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X); Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X)
9 IEO European Institute of Oncology IRCCS, International Breast Cancer Study Group Central Pathology Office, Department of Pathology and Laboratory Medicine, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843); University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
10 University of British Columbia, Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
11 Indiana University Simon Cancer Center, Department of Pathology and Laboratory Medicine, Indianapolis, USA (GRID:grid.257413.6) (ISNI:0000 0001 2287 3919)
12 Université Paris-Saclay, Service de Biostatistique et d’Epidémiologie, Gustave Roussy, CESP, Université-Paris Sud, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535); Université Paris-Saclay, CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535)
13 M.D. Anderson Cancer Center, Department of Pathology, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
14 Université Libre de Bruxelles, Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Brussels, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 0746)
15 Yale School of Medicine, Department of Pathology, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710); Yale University School of Medicine, Department of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
16 National Cancer Institute, Laboratory of Pathology, Center for Cancer Research, Bethesda, USA (GRID:grid.48336.3a) (ISNI:0000 0004 1936 8075)
17 Charité Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662); Philipps-University Marburg, Institute of Pathology, Marburg, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756)
18 German Breast Group, Neu-Isenburg, Germany (GRID:grid.434440.3) (ISNI:0000 0004 0457 2954)
19 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
20 Ontario Institute for Cancer Research, Toronto, Canada (GRID:grid.419890.d) (ISNI:0000 0004 0626 690X); IGMM, Edinburgh, UK (GRID:grid.415854.9) (ISNI:0000 0004 0605 7892); Western General Hospital, Edinburgh Cancer Research Centre, Edinburgh, UK (GRID:grid.417068.c) (ISNI:0000 0004 0624 9907)
21 IRCCS Fondazion - Instituto Nazionale Tumori, Department of Pathology and Laboratory Medicine, Milan, Italy (GRID:grid.417893.0) (ISNI:0000 0001 0807 2568); University of Milan, School of Medicine, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
22 Harvard Medical School, Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
23 The Institute of Cancer Research, Clinical Trials and Statistics Unit, Surrey, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
24 The Institute of Cancer Research, Breast Cancer Now Toby Robins Research Centre, London, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
25 Vivactiv Ltd, Research and Development, Chesham, UK (GRID:grid.18886.3f)
26 University of Ottawa, Department of Pathology and Laboratory Medicine, Ottawa, Canada (GRID:grid.28046.38) (ISNI:0000 0001 2182 2255)
27 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); GZA-ZNA Ziekenhuizen, Department of Pathology, Antwerp, Belgium (GRID:grid.428965.4) (ISNI:0000 0004 7536 2436)
28 The Netherlands Cancer Institute, Division of Tumor Biology and Immunology, Amsterdam, The Netherlands (GRID:grid.430814.a); The Netherlands Cancer Institute, Department of Medical Oncology, Amsterdam, The Netherlands (GRID:grid.430814.a)
29 The Netherlands Cancer Institute, Division of Molecular Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a); The Netherlands Cancer Institute, Department of Pathology, Amsterdam, The Netherlands (GRID:grid.430814.a)
30 Department of Oral and Maxillofacial Diseases, Helsinki, Finland (GRID:grid.430814.a)
31 Department of Pathology, Matsuyama Shimin Hospital, Matsuyama, Japan (GRID:grid.459780.7) (ISNI:0000 0004 1772 4320)
32 Surgical Oncology, Baylor College of Medicine, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X)
33 Roche Diagnostics, Mechelen, Belgium (GRID:grid.39382.33)
34 Departments of Pathology, Genomic Medicine, Dermatology, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
35 PhenoPath Laboratories, Seattle, USA (GRID:grid.240145.6)
36 Research Pathology, Genentech Inc., South San Francisco, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
37 University of Turin/Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy (GRID:grid.7605.4) (ISNI:0000 0001 2336 6580)
38 Case Western Reserve University, Cleveland, USA (GRID:grid.67105.35) (ISNI:0000 0001 2164 3847); Louis Stokes Cleveland Veterans Health Administration Medical Center, Cleveland, USA (GRID:grid.67105.35)
39 Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, USA (GRID:grid.137628.9) (ISNI:0000 0004 1936 8753)
40 Department of Pathology, Johns Hopkins Hospital, Baltimore, USA (GRID:grid.411935.b) (ISNI:0000 0001 2192 2723)
41 Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
42 PathAI, Inc, Cambridge, USA (GRID:grid.479429.5)
43 Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, USA (GRID:grid.412584.e) (ISNI:0000 0004 0434 9816)
44 Department of Oncology, IVO, Valencia, Spain (GRID:grid.418082.7) (ISNI:0000 0004 1771 144X)
45 Cancer Bioinformatics Lab, Cancer Centre at Guy’s Hospital, London, UK (GRID:grid.239826.4) (ISNI:0000 0004 0391 895X); School of Life Sciences and Medicine, King’s College London, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
46 Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Oncology and Pathology, Lund, Sweden (GRID:grid.13097.3c)
47 Dana Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910)
48 Institut Curie, Paris Sciences Lettres Université, Inserm U934, Department of Pathology, Paris, France (GRID:grid.65499.37)
49 Department of Surgical Pathology, Zealand University Hospital, Køge, Denmark (GRID:grid.476266.7)
50 Department of Biomedical Informatics, Emory University, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502)
51 Departments of Pathology and Oncology, The Johns Hopkins Hospital, Baltimore, USA (GRID:grid.411935.b) (ISNI:0000 0001 2192 2723)
52 National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
53 Department of Pathology, Karolinska Institutet, Karolinska, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626)
54 Department of Pathology, New York University Langone Medical Centre, New York, USA (GRID:grid.4714.6)
55 Department of Pathology and Laboratory Medicine, UNC School of Medicine, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208)
56 Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, Toronto, Canada (GRID:grid.10698.36)
57 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434)
58 Department of Medicine, University of Melbourne, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
59 Trev & Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, Canada (GRID:grid.248762.d) (ISNI:0000 0001 0702 3000)
60 Division of Imaging, Diagnostics, and Software Reliability (DIDSR), Office of Science and Engineering Laboratories (OSEL), Center for Devices and Radiological Health (CDRH), Rockville, USA (GRID:grid.413579.d) (ISNI:0000 0001 2285 9893)
61 Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024); Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
62 Providence Cancer Research Center, Portland, Oregon, USA (GRID:grid.419177.d)
63 Department of Medical Oncology, Istituto Europeo di Oncologia, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843)
64 Roche Diagnostics, Mechelen, Belgium (GRID:grid.15667.33)
65 Department of Pathology, AZ Turnhout, Turnhout, Belgium (GRID:grid.476094.8)
66 Department of Pathology, St Vincent’s University Hospital and University College Dublin, Dublin, Ireland (GRID:grid.7886.1) (ISNI:0000 0001 0768 2743)
67 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
68 Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
69 Azienda AUSL, Regional Hospital of Aosta, Aosta, Italy (GRID:grid.83440.3b)
70 Université Paris-Sud, Institut National de la Santé et de la Recherche Médicale, Villejuif, France (GRID:grid.5842.b) (ISNI:0000 0001 2171 2558); Gustave Roussy, Universite Paris-Saclay, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
71 University Hospital Halle (Saale), Institute of Pathology, Halle, Germany (GRID:grid.461820.9) (ISNI:0000 0004 0390 1701)
72 Department of Pathology, UCL Cancer Institute, UCL, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201); University College Hospitals NHS Trust, London, UK (GRID:grid.52996.31) (ISNI:0000 0000 8937 2257)
73 Department of Pathology, Jules Bordet Institute, Brussels, Belgium (GRID:grid.418119.4) (ISNI:0000 0001 0684 291X)
74 Department of Clinical Medicine, Macquarie University, Sydney, Australia (GRID:grid.1004.5) (ISNI:0000 0001 2158 5405)
75 HistoGeneX NV, Antwerp, Belgium and AZ Sint-Maarten Hospital, Mechelen, Belgium (GRID:grid.1004.5)
76 Oncology Clinical Development, Bristol-Myers Squibb, Princeton, USA (GRID:grid.419971.3)
77 Institut für Pathologie, UK Hamburg, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
78 Department of Medicine, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
79 Department of Cancer CV, Jacksonville, USA (GRID:grid.412807.8)
80 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
81 Department of Oncology, Mayo Clinic, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
82 Roche, Tucson, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
83 Department of Pathology, Herlev and Gentofte Hospital, Gentofte, Denmark (GRID:grid.411646.0) (ISNI:0000 0004 0646 7402)
84 Université Paris-Saclay, Univ. Paris-Sud, Villejuif, France (GRID:grid.5842.b) (ISNI:0000 0001 2171 2558); Service de biostatistique et d’épidémiologie, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
85 Yale School of Medicine, Department of Pathology, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
86 Department of Pathology, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552); Departamento de Anatomía Patológica, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552)
87 Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center, Gliwice, Poland (GRID:grid.418165.f) (ISNI:0000 0004 0540 2543)
88 Pathology and Tissue Analytics, Roche, Neuherberg, Germany (GRID:grid.424277.0)
89 Department of Medical Oncology, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
90 Sunnybrook Health Sciences Centre, Toronto, Canada (GRID:grid.413104.3) (ISNI:0000 0000 9743 1587)
91 Tehran University of Medical Sciences, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
92 Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain (GRID:grid.5515.4) (ISNI:0000000119578126); GEICAM-Spanish Breast Cancer Research Group, Madrid, Spain (GRID:grid.430580.a)
93 Translational Research, Montreal, Canada (GRID:grid.430580.a)
94 Computational Pathology Group, Department of Pathology, Nijmegen, The Netherlands (GRID:grid.430580.a)
95 Oncology Biomarker Development, Genentech-Roche, Neuherberg, Germany (GRID:grid.430580.a)
96 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA (GRID:grid.430503.1) (ISNI:0000 0001 0703 675X)
97 Charité Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany (GRID:grid.6363.0) (ISNI:0000 0001 2218 4662)
98 Centre de Lutte Contre le cancer - Centre Jean Perrin, Clermont-Ferrand, France (GRID:grid.418113.e) (ISNI:0000 0004 1795 1689)
99 Department of Pathology, Hospital de Oncología Maria Curie, Buenos Aires, Argentina (GRID:grid.418113.e)
100 Directorate of Surgical Pathology, SA Pathology, Adelaide, Australia (GRID:grid.414733.6) (ISNI:0000 0001 2294 430X)
101 Department of Pathology, GZA-ZNA Ziekenhuizen, Wilrijk, Belgium (GRID:grid.414733.6)
102 University of Milano, Instituto Europeo di Oncologia, IRCCS, Milano, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822); Division of Early Drug Development for Innovative Therapy, IEO, European Institute of Oncology IRCCS, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843)
103 Department of Imaging and Pathology, Laboratory of TranslCal Cell & Tissue Research, Leuven, Belgium (GRID:grid.15667.33); KU Leuven- University Hospitals Leuven, Department of Pathology, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
104 Department of Pathology, University Hospital of Antwerp, Antwerp, Belgium (GRID:grid.411414.5) (ISNI:0000 0004 0626 3418)
105 Paula I, Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
106 Translational Health Sciences, Department of Cellular Pathology, North Bristol NHS Trust, University of Bristol, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603)
107 Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA (GRID:grid.50956.3f) (ISNI:0000 0001 2152 9905)
108 Helsinki University Central Hospital, Helsinki, Finland (GRID:grid.15485.3d) (ISNI:0000 0000 9950 5666)
109 Department of Clinical Pathology, Akademiska University Hospital, Uppsala, Sweden (GRID:grid.412354.5) (ISNI:0000 0001 2351 3333)
110 Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan (GRID:grid.412094.a) (ISNI:0000 0004 0572 7815)
111 Department of Oncology, National Taiwan University Cancer Center, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241)
112 International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (GRID:grid.17703.32) (ISNI:0000000405980095)
113 Department of Pathology, Sanatorio Mater Dei, Buenos Aires, Argentina (GRID:grid.17703.32)
114 Institute of Pathology, Medical University of Graz, Graz, Austria (GRID:grid.11598.34) (ISNI:0000 0000 8988 2476)
115 Department of Oncology, National Cancer Centre Singapore, Singapore, Singapore (GRID:grid.410724.4) (ISNI:0000 0004 0620 9745)
116 Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294)
117 Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands (GRID:grid.430814.a)
118 PathAI Inc, Cambridge, USA (GRID:grid.479429.5)
119 Visiopharm A/S, Hørsholm, Denmark (GRID:grid.479429.5); DTU Compute, Department of Applied Mathematics, Technical University of Denmark, Lyngby, Denmark (GRID:grid.5170.3) (ISNI:0000 0001 2181 8870)
120 Nuffield Department of Population Health, University of Oxford, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948); Department of Medical Oncology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK (GRID:grid.410421.2) (ISNI:0000 0004 0380 7336)
121 Computational Pathology Group, Department of Pathology, Nijmegen, The Netherlands (GRID:grid.410421.2)
122 R&D UNICANCER, Paris, France (GRID:grid.410421.2)
123 Translational Sciences, MedImmune, Gaithersberg, USA (GRID:grid.418152.b)
124 Breast Unit, Champalimaud Clinical Centre, Lisboa, Portugal (GRID:grid.418152.b)
125 Department of Pathology, Massachusetts General Hospital, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924)
126 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
127 Biomedical Informatics Department, Stony Brook University, Stony Brook, USA (GRID:grid.36425.36) (ISNI:0000 0001 2216 9681)
128 Department of Oncology and Pathology, Karolinska Institutet and University Hospital, Solna, Sweden (GRID:grid.24381.3c) (ISNI:0000 0000 9241 5705)
129 Department of Medicine, Clinical Division of Oncology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)
130 Leicester Cancer Research Centre, University of Leicester, Leicester, and MRC Toxicology Unit, University of Cambridge, Cambridge, UK (GRID:grid.5335.0) (ISNI:0000000121885934)
131 Merck & Co., Inc, Kenilworth, USA (GRID:grid.417993.1) (ISNI:0000 0001 2260 0793)
132 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952); Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
133 Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
134 Department of Medicine, Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein Medical Center, Bronx, USA (GRID:grid.419177.d)
135 GHI Le Raincy-Montfermeil, Chelles, Île-de-France, France (GRID:grid.420138.c) (ISNI:0000 0000 8620 9964)
136 Department of Pathology, Universidad de La Frontera, Temuco, Chile (GRID:grid.412163.3) (ISNI:0000 0001 2287 9552)
137 Department of Pathology, Gustave Roussy, Grand Paris, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
138 Departments of Medicine and Cancer Biology, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
139 VMscope GmbH, Berlin, Germany (GRID:grid.412807.8)
140 Department of Pathology, Breast Pathology Section, Northwestern University, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)
141 Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.16753.36)
142 NSABP/NRG Oncology, Pittsburgh, USA (GRID:grid.434440.3)
143 Division of Molecular Pathology, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK (GRID:grid.18886.3f) (ISNI:0000 0001 1271 4623)
144 Cancer Biomarkers Working Group, Faculty of Medicine and Pharmacy, Université Mohamed Premier, Oujda, Morocco (GRID:grid.410890.4) (ISNI:0000 0004 1772 8348)
145 Yale Cancer Center Genetics, Genomics and Epigenetics Program, Yale School of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710)
146 Pathology Department, Stanford University Medical Centre, Stanford, USA (GRID:grid.47100.32)
147 Pathology and Tissue Analytics, Roche Innovation Centre Munich, Penzberg, Germany (GRID:grid.47100.32)
148 Pathology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811); GEICAM-Spanish Breast Cancer Research Group, Madrid, Spain (GRID:grid.430580.a)
149 Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.430580.a)
150 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)
151 Center for Pharmacogenomics and Fudan-Zhangjiang, Center for Clinical Genomics School of Life Sciences and Shanghai Cancer Center, Fudan University, Fudan, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443)
152 GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre and Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands (GRID:grid.412966.e) (ISNI:0000 0004 0480 1382)
153 Oncology Biomarker Development, Genentech-Roche, Neuherberg, Germany (GRID:grid.412966.e)
154 Biorepository and Tissue Technology Shared Resources, University of California San Diego, San Diego, USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)
155 Department of Pathology, Gustave Roussy, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
156 Departments of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776)
157 Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands (GRID:grid.5650.6) (ISNI:0000000404654431)
158 Department of Pathology, University of São Paulo, São Paulo, Brazil (GRID:grid.11899.38) (ISNI:0000 0004 1937 0722); Hospital das Clínicas, Sao Paulo, Brasil (GRID:grid.411074.7) (ISNI:0000 0001 2297 2036)
159 Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470)
160 Department of Medical Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France (GRID:grid.14925.3b) (ISNI:0000 0001 2284 9388)
161 Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium (GRID:grid.418119.4) (ISNI:0000 0001 0684 291X)
162 Roche Tissue Diagnostics, Digital Pathology, Santa Clara, USA (GRID:grid.22937.3d)
163 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Centre, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
164 Division of Biostatistics, Dana-Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
165 Roche Diagnostics Information Solutions, Belmont, USA (GRID:grid.418158.1) (ISNI:0000 0004 0534 4718)
166 Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Australia (GRID:grid.416153.4) (ISNI:0000 0004 0624 1200)
167 Vernon Cancer Center, Newton-Wellesley Hospital, Newton, USA (GRID:grid.416176.3) (ISNI:0000 0000 9957 1751)
168 Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.416176.3)
169 Service de pathologique, Cliniques universitaires Saint-Luc, Bruxelles, Belgique (GRID:grid.48769.34) (ISNI:0000 0004 0461 6320)
170 Department of Research, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru (GRID:grid.419177.d) (ISNI:0000 0004 0644 4024)
171 Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502)
172 Breast Center, Dept. OB&GYN and CCC (LMU), University of Munich, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X)
173 Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, USA (GRID:grid.239395.7) (ISNI:0000 0000 9011 8547)
174 University of Leuven, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
175 Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.5596.f)
176 Université Paris-Saclay, Service de Biostatistique et d’Epidémiologie, Gustave Roussy, CESP, Université-Paris Sud, Villejuif, France (GRID:grid.460789.4) (ISNI:0000 0004 4910 6535)
177 Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France (GRID:grid.460789.4)
178 Johanniter GmbH - Evangelisches Krankenhaus Bethesda Mönchengladbach, West German Study Group, Mönchengladbach, Germany (GRID:grid.476830.e)
179 Molecular Oncology Group, Vall d’Hebron Institute of Oncology, Barcelona, Spain (GRID:grid.411083.f) (ISNI:0000 0001 0675 8654)
180 Department of Pathology, University of Marburg, Marburg, Germany (GRID:grid.10253.35) (ISNI:0000 0004 1936 9756)
181 Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
182 Department of Histopathology, Manipal Hospitals Dwarka, New Delhi, India (GRID:grid.412807.8)
183 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
184 University of Melbourne, Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
185 Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
186 Department of Anatomical Pathology, St Vincent’s Hospital Melbourne, Fitzroy, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560)
187 Icahn School of Medicine at Mt. Sinai, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351)
188 NRG Oncology/NSABP, Pittsburgh, USA (GRID:grid.59734.3c)
189 Cancer Immunotherapy Trials Network, Central Laboratory and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, USA (GRID:grid.270240.3) (ISNI:0000 0001 2180 1622)
190 Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
191 Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (GRID:grid.66875.3a)
192 Department of Pathology, Fudan University Cancer Center, Shanghai, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443)
193 Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium (GRID:grid.428965.4) (ISNI:0000 0004 7536 2436)
194 University of British Columbia, Vancouver, Canada (GRID:grid.17091.3e) (ISNI:0000 0001 2288 9830)
195 Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Research Institute, Toronto, Canada (GRID:grid.17063.33) (ISNI:0000 0001 2157 2938)
196 Merck Oncology, Kenilworth, USA (GRID:grid.17063.33)
197 The Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia (GRID:grid.415306.5) (ISNI:0000 0000 9983 6924)
198 Georgetown University Medical Center, Washington, USA (GRID:grid.411667.3) (ISNI:0000 0001 2186 0438)
199 FDA/CDRH/OSEL/Division of Imaging, Diagnostics, and Software Reliability, Silver Spring, USA (GRID:grid.411667.3)
200 Department of Molecular and Experimental Medicine, Avera Cancer Institute, Sioux Falls, USA (GRID:grid.414118.9) (ISNI:0000 0004 0464 4831)
201 Translational Medicine, Bristol-Myers Squibb, Princeton, USA (GRID:grid.419971.3)
202 Anatomic Pathology, Boston, USA (GRID:grid.21925.3d)
203 Guy’s Hospital, London, UK (GRID:grid.239826.4) (ISNI:0000 0004 0391 895X); King’s College London, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
204 Peking University First Hospital Breast Disease Center, Beijing, China (GRID:grid.411472.5) (ISNI:0000 0004 1764 1621)
205 Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia (GRID:grid.1055.1) (ISNI:0000000403978434)
206 Dipartimento di Scienze della Salute (DSS), Firenze, Italy (GRID:grid.1055.1)
207 Department of Oncology, Champalimaud Clinical Centre, Lisbon, Portugal (GRID:grid.1055.1)
208 Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Berlin, Germany (GRID:grid.21925.3d)
209 Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045)
210 Harvard Medical School, Department of Pathology, Brigham and Women’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Dana-Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910)
211 Department of Pathology, Fundación Valle del Lili, Cali, Valle del Cauca, Colombia (GRID:grid.477264.4)
212 The University of Queensland Centre for Clinical Research and Pathology Queensland, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537)
213 Department of Pathology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, USA (GRID:grid.240283.f) (ISNI:0000 0001 2152 0791)
214 Department of Pathology, University Hospital of Bellvitge, Oncobell, IDIBELL, L’Hospitalet del Llobregat, Barcelona, Spain (GRID:grid.240283.f)
215 Department of Development and Regeneration, Laboratory of Experimental Urology, KU Leuven, Leuven, Belgium (GRID:grid.5596.f) (ISNI:0000 0001 0668 7884)
216 Department of Medical Oncology, Austin Health, Heidelberg, Australia (GRID:grid.410678.c)
217 Department of Surgery, Kansai Medical School, Hirakata, Japan (GRID:grid.410783.9) (ISNI:0000 0001 2172 5041)
218 Roche Tissue Diagnostics, Digital Pathology, Santa Clara, USA (GRID:grid.410783.9)
219 Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, Toronto, Canada (GRID:grid.32224.35)
220 Pathology Department, H.U. Vall d’Hebron, Barcelona, Spain (GRID:grid.32224.35)
221 Division of Bioinformatics and Biostatistics, US Food and Drug Administration, Silver Spring, USA (GRID:grid.417587.8) (ISNI:0000 0001 2243 3366)
222 Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Providence, USA (GRID:grid.17063.33)
223 Université Paris-Est, Créteil, France (GRID:grid.410511.0) (ISNI:0000 0001 2149 7878)
224 Praava Health, Dhaka, Bangladesh (GRID:grid.410511.0)
225 Department of Pathology, Medical University of Vienna, Vienna, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)
Publication year
2020
Publication date
2020
e-ISSN
23744677
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2488351543
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.