A Methodology for Mapping the Patient Journey for Noncommunicable Diseases in Low- and Middle-Income Countries

Abstract

Noncommunicable diseases (NCDs) are responsible for 71% of all worldwide mortality each year, and have an exceptionally large impact in low- and middle-income countries (LMICs). However, there is often a lack of local data from these countries to inform practice and policy improvements. Generating locally contextualized evidence base for NCDs that can help identify gaps, aid decision-making and improve patient care in LMICs needs an innovative approach. The approach used in Mapping the Patient Journey Towards Actionable Beyond the Pill Solutions (MAPS) is designed to quantitatively map different stages of the patient journey in four critical NCDs, ie, hypertension, dyslipidemia, depression, and pain (chronic and neuropathic) across selected LMICs in Africa, the Middle East, South East Asia, and Latin America. The key touchpoints along the patient journey include awareness, screening, diagnosis, treatment, adherence, and control or remission. MAPS employs an evidence mapping methodology that follows a three-step semi-systematic review: 1) systematic peer-reviewed database search; 2) unstructured searches of local or real-world data; and 3) expert opinion. Evidence generation and visualization is based on locally validated and deduplicated data published over the last 10 years. This approach will be the first to provide quantitative mapping of the different stages of the patient journey for selected NCDs in LMICs. By focusing on local, patient-centric data, the goal of the MAPS initiative is to address and prioritize local research and knowledge gaps, then contribute to evidence-based, high-quality, and affordable advances in the management of NCDs in LMICs. This will ultimately improve patient outcomes and contribute towards the achievement of global NCD targets.

Introduction

Noncommunicable disease (NCD) is a collective term for a number of non-infectious diseases, including cardiovascular disease, cancer, diabetes, chronic respiratory disease, mental health problems and neurological disorders, and other chronic conditions. Together, NCDs are responsible for 71% of all worldwide mortality each year,¹ and 44% of all NCD deaths are due to cardiovascular disease.² Over a third of all NCD deaths occur prematurely, between the ages of 30 and 69 years, and the majority (85%) of these premature deaths occur in low- and middle-income countries (LMICs).¹ Premature mortality in LMICs results in cumulative economic losses of US$7 trillion and contributes to the vicious cycle of poverty and inequity in these countries.³

Nearly two-thirds of all NCDs are linked to one or more shared risk factors, including tobacco use, unhealthy diet, physical inactivity, alcohol abuse, and air pollution.⁴ These can be addressed by strategies that include proper information provision and equitable access to effective healthcare.³ However, the lack of infrastructure, skilled human resources, and financial investment required to formulate effective policies and actions in LMICs make this problematic.⁵ These challenges highlight an urgent need for specific data to inform country- or region-specific approaches to ensure optimal local and context-specific management of NCDs.

The World Health Organization (WHO) has developed a framework on people-centered health that shifts the focus from diseases to place the needs of people at the center of health systems.⁶ To achieve this, there is a requirement for patient-centric approaches that shift the focus from disease to what is needed along the patient journey, from the prevention of risk factors to the control of established illness. Patients with NCDs often have a non-linear journey through the health system, changing with new test results, comorbidity diagnosis or symptoms.⁷ This journey reflects a continuum of care that includes an ongoing sequence of healthcare interactions.⁸ As reported recently, the patient journey for NCDs can be classified into five broad touchpoints: awareness, screening, diagnosis, treatment, and adherence, with integration of palliative care along the care continuum pathway.⁸ Several studies in LMICs examined prevalence, awareness, treatment and control as the key epidemiological touchpoints for monitoring the gaps in hypertension and diabetes management practices.^9–11 Based on these reports, patient journeys for those with NCDs include gaining an awareness of the disease process and associated risk factors, screening for the disease, its risk factors or comorbidities, diagnosis, treatment, adherence to the prescribed treatment, and control or remission of the disease (Figure 1). In the real world, patients may not necessarily follow the touchpoints sequentially, rather entering or exiting at any stage and may often need support and care at other points.⁸ These touchpoints are well researched and documented in developed countries but remain less evaluated in LMICs. This can result in the use of global data to inform local healthcare, which might not be accurate or appropriate. In contrast, reliable and accurate local evidence helps to identify relevant problems, inform the modification of international evidence, and facilitate the development of locally relevant and feasible solutions. Locally generated health policy systems research evidence has successfully demonstrated design and implementation of programs and policies to strengthen health systems in Mexico's Seguro Popular health insurance scheme and Thailand's national Universal Health Coverage programme.¹² Successful implementation of evidence-based policy requires not only the evidence of effectiveness of healthcare interventions, but also their cost-effectiveness, cultural appropriateness and effects on health inequalities.¹³ Similarly, the path from evidence generation to practice improvements follows multiple steps constituting knowledge of local care pathways, the clinical context and the institutional and political setting, and the patients' circumstances.¹⁴

Given the difficulties in generating and obtaining reliable NCD data in LMICs, an innovative approach is required. "Evidence mapping" is a methodology for reviewing evidence to identify gaps or future research needs.^15,16 It differs from conventional systematic approaches in that it combines a systematic process with visual depiction of results to present vast amounts of data in a user-friendly, accessible, digestible and useable format.¹⁵ Evidence mapping relies on systematically searching evidence sources, documenting decisions on article inclusion/exclusion, and objective assessment of review scope. These characteristics can lead to a standardized protocol, which can be applicable across multiple NCD settings.¹⁷ The evidence mapping approach, which includes appraisal of data by local experts to validate the evidence and address data gaps, can help with strategies for evidence-informed decision-making (EDIM). EDIM has been defined as the intentional and systematic processes of bringing the best available scientific evidence on specific questions together with other relevant information to help weigh options and inform decisions that will affect priorities, policies, programs, and practices.

¹⁸ Overall, this research strategy, which combines systematic searching with other approaches for identifying evidence, fulfils the criteria of a semi-systematic review.^19,20 The process allows the identification and analysis of all potentially relevant data on a given topic while using a transparent research approach that facilitates judgments about whether the data are rational and their usage appropriate.¹⁹

Mapping the Patient Journey Towards Actionable Beyond the Pill Solutions (MAPS) is an initiative to facilitate a patient-centric approach to improving healthcare outcomes in the context of NCDs in LMICs. The main objective is to quantitatively map the different stages of the patient journey in key NCDs across selected LMICs. A secondary aim is to generate a framework to prioritize actionable gaps in the patient journey for those NCDs and propose strategic recommendations for "beyond-the-pill" solutions that will benefit patients and support decision-making. This paper presents the methodology for generating the evidence map of patient journeys for NCDs in LMICs.

Description of MAPS Study Design

The first phase of the MAPS initiative will focus on four NCDs: hypertension, dyslipidemia, depression (major depressive disorder), and pain (chronic and neuropathic). The selected NCDs represent the leading contributors of deaths and disability worldwide and in LMICs.^21–23 Cardiovascular diseases have been identified as the leading cause of NCD-related mortality worldwide, accounting for 17.8 million deaths, based on estimates from the WHO and the Global Burden of Disease Study 2017.^1,24 Hypertension is the leading driver of cardiovascular diseases and the leading risk factor for mortality.²⁵ Raised blood pressure accounting for 10.4 million deaths and 218 million disability adjusted life-years (DALYs), in 2017, was the leading metabolic risk factor for cardiovascular disease burden globally.²² It is estimated that by 2025, over 75% of world's hypertensive population will reside in LMICs.²⁶ Raised total cholesterol, accounting for 4.4 million deaths and 93.8 million DALYs in 2016, was also an important metabolic risk factor for global cardiovascular disease burden.²⁷ In terms of measuring the impact of NCDs on individuals, communities and health services, years lived with disability (YLDs) present the prevalence and severity of the disease. In 2017, chronic low back pain (65 million YLDs) was the leading cause of YLDs, followed by headache (54 million YLDs) and depressive disorders (43 million YLDs).²¹ Pain disorders—low back pain and headache—and depressive disorder have been the prevailing cause of non-fatal disability for over three decades.²¹ LMICs from Africa and the Middle East (AFME; Algeria, Egypt, Saudi Arabia, South Africa, and the United Arab Emirates), South East Asia (Malaysia, Philippines, Thailand, and Vietnam), and Latin America (LATAM; Argentina, Brazil, and Mexico) will be studied. Stages included in the patient journey are awareness, screening, diagnosis, treatment, adherence, and control or remission. An evidence mapping methodology will be employed which will follow a semi-systematic review of three sources of evidence: 1) systematic peer-reviewed database search; 2) unstructured searches of local or real-world data; and 3) expert opinion. The evidence mapping process will start with a systematic data review where possible. However, if there is a lack of data in some areas, the search strategy and evidence sources will be adjusted to ensure the availability of sufficient relevant information for meaningful analysis. The overall process for collecting and analyzing the data is illustrated in Figure 2.

Sources of Evidence Systematic Peer-Reviewed Database Search

Structured searches will be conducted across three electronic databases (Embase, MEDLINE, and BIOSIS) for records published in the English language over the previous 10 years. The 10-year time period has been chosen because it provides a balance between availability, currency, and relevance of data from LMICs. Search strings for the four included NCDs with the appropriate disease MeSH terms, and their synonyms, patient journey stages, and LMIC regions will be queried (Table S1).

Inclusion and Exclusion Criteria Studies identified from the systematic database search will be included in the analysis if they meet the following criteria:

* A systematic review and/or metanalysis, randomized controlled study, observational study (including case-control, cohort, cross-sectional, longitudinal, retrospective chart review, survey study types), narrative reviews (both full articles and conference abstracts)

* Human data from adult populations aged ≥18 years

* Patient populations with hypertension, hypercholesterolemia, depression, or pain (chronic or neuropathic):

* Hypertension is defined as average (SBP) ≥140 mmHg and/or average diastolic blood pressure (DBP) ≥90 mmHg²⁸

* Hypercholesterolemia is defined as total cholesterol (TC) level ≥5.0 mmol/L or ≥200.0 mg/dL^29–32

* Depression is defined according to the criteria common to the Diagnostic and Statistical Manual (DSM)-III,³³ DSM-IV,³⁴ and DSM-V:³⁵ the presence of ≥5 symptoms in the last 2 weeks with >1 symptom being either depressed mood or the loss of interest or pleasure

* Chronic pain is defined as pain lasting >3 months,³⁶ including osteoarthritis and low back pain

* Neuropathic pain is defined as pain due to lesion or disease of the somatosensory system,^37,38 including diabetic peripheral neuropathy and low back pain with a neuropathic component * Reporting quantitative epidemiological data for each stage of the patient journey (awareness, screening, diagnosis, treatment, adherence, and control or remission) in hypertension,⁹ dyslipidemia,³⁹ depression,⁴⁰ and pain⁴¹ (chronic and neuropathic) (Table 1)

* Data from selected LMICs.

Studies published before 2010, non-English language publications, case studies, letters to the editor, editorials, studies including specific patient subgroups (eg, those with comorbidities, pregnant women, etc), and duplicate records will be excluded.

Unstructured Search

To address any gaps in systematic searches (particularly relating to specific local data), structured searches will be supplemented by searching the Incidence and Prevalence Database (IPD), the WHO website, National Ministry of Health websites for the relevant countries, national clinical practice and treatment guidelines, and Google (the Google search will include a combination of the key MeSH terms from the systematic literature search). There will be no date limits on material identified in the unstructured searches.

Expert Opinion

Any data gaps identified in the patient journey following the systematic and unstructured searches will be addressed through studies published in local languages and/or anecdotal data sought from local experts in the four NCD areas contacted via face-to-face meetings or telephonic discussions. These local experts will be national or leading health specialists in each disease area (for example, leaders of local medical associations, academic consultants in leading hospitals, or leaders of national Ministry of Health projects) who also fulfill pre-specified selection criteria: 1) academic and vocational qualifications in the specialty to be reviewed; 2) research interest and achievement in their field of specialty; 3) authors of relevant articles published in peer-reviewed journals; 4) members of a relevant national professional society; and 5) recognized as leaders by their peers. The goal will be to have 1–3 experts from each country.

An Ethics Board approval will be sought, as applicable, at the time of data collection from local experts.

Data Synthesis, Verification, and Analysis

Systematic and unstructured searches will be conducted by an independent reviewer, and the title and abstract of each article will be sequentially screened against the inclusion and exclusion criteria. The results of these searches (including general information about the article, including the title, article citation, author names, year of publication, abstract, study design, study participants, and study setting) will be reviewed by a second independent reviewer who will exclude non-relevant studies; any disagreements will be resolved through discussion between the two reviewers. In order to detect large effect, as expected for the patient journey stages, large sample size would not be needed and a nationally representative population sample size of 500 will be considered adequate for this analysis.⁴² Where nationally representative populations from studies with a sample size of ≥500 are not available, data points from studies that include only a population sub-group, single-center experience, or sample size of <500 will be eligible for inclusion. Hierarchy of evidence recognizes higher ranking of evidence coming from studies that are multicenter and with multiple populations, settings, and circumstances.⁴³

When information from adequately powered studies is not available, combined data from the systematic and unstructured searches, local sources and expert opinion will then be used to synthesize data for each patient journey touchpoint across each NCD using appropriate measures of central tendency (point estimates of weighted mean or simple average) to minimize bias arising from the methodological limitations of different studies. The resulting dataset will be exported into a Microsoft Excel document, and quantitative data will be categorized according to the NCD, country, and step in the patient journey. The data will then be verified by ≥1 local expert to ensure consistency with real-world insights and expert opinion. Additionally, the study design of shortlisted studies will be appraised to assign corresponding level of evidence based on the levels developed by the Centre for Evidence Based Medicine.^44,45 The synthesized evidence or lack thereof will be depicted visually as evidence maps or gaps for each of the four NCDs in each of the 12 LMICs being studied to provide an overview of the unmet needs along the patient journey and identify areas where there is an evidence gap due to a lack of local, reliable, and good-quality data.

Data Visualization

An important element of evidence mapping is exploration and mapping of evidence through data visualization.¹⁵ The point estimates from each patient journey component will be visualized as doughnut charts depicted in different colors to highlight the gaps quantitatively in each patient journey stage (Figure 3). Further, the point estimates will be extrapolated to data at the national level to estimate disease burden as the absolute number of patients at-risk (prevalence), remaining undiagnosed, being untreated and uncontrolled for their conditions in the respective LMICs, sequentially along the patient journey and presented as a funnel diagram (Figure 4). An evidence map of NCD patient journey for each condition across each LMIC will be presented as a bubble plot (Figure 5), where the coordinates of each bubble correspond to a specific touchpoint and the number of supporting evidence sources and the size of the bubble corresponds to the estimated effect size of the touchpoint.

Discussion

In this paper, we describe a novel approach to identifying and verifying local country data for four NCDs and chronic conditions in selected LMICs. The subsequent analyses will be the first to provide a quantitative mapping of local information along the different stages of the patient journey for these conditions. Understanding patient journey data in this manner has benefits for all stakeholders. The information will support healthcare professionals to better appreciate the patient's perspective and bridge gaps in clinical practice.⁴⁶ Policymakers and health system managers can utilize the data to review and address deficiencies in health policy; and inform resource allocation, healthcare workforce, capability development and integration of NCD care, and improve efficiencies.⁴⁷ Patients stand to gain from these improvements with paths to greater health literacy and processes that enable greater participation in managing their health.⁴⁸ The gaps in the mapped evidence can be transformed into beyond-the-pill solutions by bringing together traditional and non-traditional stakeholders for NCD management. The MAPS process will thus deliver an opportunity to use relevant local information rather than the need to extrapolate generic international data. This is the rationale for the study.

Although it is widely recognized that NCDs are a significant issue for development and sustainability in LMICs,^1,3 programs to reduce the burden of NCDs have been limited by a lack of specific information on the design and implementation of these initiatives, and on their long-term impact.⁴⁹ There are other systemic, social, and financial barriers in LMICs that retard the translation of evidence into policy and practice improvements.¹³ Strengthening local research capacity is essential, as noted in the WHO Global Action Plan for the Prevention and Control of NCDs 2013–2020.³ This is a critical way to help LMICs to reach global NCD targets by 2025.⁵⁰ Resilient and responsive health systems require decision makers and health actors to identify, collect, and interpret local evidence while responding to new or emerging healthcare challenges, and monitor periodically.⁴⁷ By focusing on local, patient-centric data, the goal of the MAPS initiative is to address and prioritize research and knowledge gaps, then provide support and recommendations to improve patient care and decision-making to effectively tackle NCDs in LMICs.

True systematic reviews may not always be feasible for informing pressing public health issues and decisions. Policy decisions must be informed from a broad knowledge base from scientific evidence, grey literature and tacit knowledge of local healthcare professionals for contextualized evidence.⁵¹ The semi-systematic review has been identified as a good strategy for mapping theoretical approaches or themes, and for identifying knowledge gaps within the literature.¹⁹ An important limitation for MAPS in its current iteration is the absolute lack of data from LMICs in some areas. Therefore, the semi-systematic approach is being used to ensure that as much relevant data as possible are included and to minimize data gaps given the high importance of NCDs in LMICs. However, the lack of patient registries and infrastructure, and a segmented approach to care in some LMICs makes this problematic.⁵² Also, it highlights the importance of the MAPS process to address these gaps. Accurate local data will allow recommendations based on international evidence to be tailored for different countries, providing a targeted and practical approach to patient management. Local evaluation activities have the most influence on public health decision-making as they meet the requirements of locality of evidence, and thereby transferability of evidence.⁵³ The value of experiential knowledge and opinions of local experts in public health decision-making is highlighted by their frequent utilization along with other robust forms of evidence including national guidelines and systematic reviews and meta-analysis, even in developed countries.^53–55 A similar semi-systematic approach based on a combination of literature review, expert opinion, and stakeholder feedback has been used to inform the development of public health intervention research on novel psychoactive substances in the United Kingdom.⁵⁶ The lack of specific data in that field is comparable to the issues relating to NCDs in LMICs, highlighting the usefulness of the semi-systematic approach in these settings. There is evidence that employing supplementary search techniques, such as unstructured/citation searches, grey literature searches and contact with experts, in combination with systematic searches identified a greater proportion of higher quality articles in the psychiatry and social sciences fields with poorly defined concepts/themes and variability in indexing.⁵⁷

NCDs include a number of common conditions, including cardiovascular diseases, cancer, diabetes, chronic respiratory diseases, and mental health and neurological disorders.⁵⁸ The areas of focus for the current analyses are cardiovascular disease (hypertension and dyslipidemia), chronic pain, and depression. The prevalence, diagnostic criteria, and treatment guidelines for these NCDs will vary between LMICs. For example, low-density lipoprotein cholesterol (LDL-C) is considered a more sensitive marker for determination of atherosclerotic cardiovascular disease risk, though in most LMICs total cholesterol tests are preferred due to their low cost and availability.^59,60 For ease of data collection, commonly recognized definitions and classifications, as outlined in international guidelines, will be used in the MAPS approach. In addition, we considered pharmacotherapy as a measure of treatment in NCD patients. However, the treatment of NCDs such as hypertension frequently involves the use of medication along with lifestyle modifications targeting the major modifiable risk factors (in the case of hypertension, these include salt intake, unhealthy diet, excessive alcohol consumption, smoking, physical inactivity, stress, and air pollution).⁶¹ We felt that it was important to make a start on providing essential local data in LMICs, despite limiting the analysis to specific conditions and parameters. Additional research investigating diabetes, cancer, and chronic respiratory diseases will be required to obtain a comprehensive picture of the four key groups of NCDs in LMICs. Our evidence mapping exercise could potentially serve as a roadmap for future collaborations to generate evidence on other factors playing a role in the NCD patient journey that are not included in the current analyses.

The importance and relevance of including both cardiovascular disease and mental health issues in the initial MAPS analysis have been emphasized by the coronavirus disease (COVID-19) pandemic. Along with those aged over 65 years,^62–64 patients with NCDs such as cardiovascular disease (and diabetes or respiratory disease) are at substantially higher risk of becoming severely ill or dying if they become infected with the SARS-CoV-2 virus.⁶⁴ Furthermore, the impact of mental health issues associated with challenges such as enforced isolation and the financial impact of the pandemic for an extended period of time will likely outlast the virus in the community, highlighting the need for both urgent and ongoing mental health strategies.⁶⁵ The strain placed on healthcare services by the need to care for large numbers of COVID-19 patients and the requirement for physical distancing has meant that services for the prevention and treatment of NCDs have been substantially disrupted in many countries, which could result in a long-term increase in NCD-related morbidity and mortality.⁶⁶ This is likely to disproportionately affect LMICs, where there are high rates of COVID-19 and also less robust healthcare systems, and therefore highlights the importance of approaches designed to improve future management of NCDs in these countries.

A key strength of this study design is the use of a semi-systematic approach to ensure maximum coverage of data in the patient journey. Local applicability will be maximized by the validation of data by local experts.^53–55 However, several limitations will be unavoidable. These include the risk of several forms of bias,⁶⁷ such as from a lack of quality assessment,⁶⁸ and the possibility of publication bias (although the semi-systematic approach should limit this). The exclusion of non-clinical study types, such as case reports and letters to the editor, means that data published in these formats will not be captured in the analysis. Inclusion of only English language studies results in a language bias that is relatively common in systematic reviews,⁶⁹ but this should be minimized by an attempt to include local language studies during the data validation step by local experts. Another potential limitation of this study could be the lack of a standardized questionnaire for data verification. There may also be limitations around the concepts used in specific disease areas, such as the focus on pharmacological treatment for hypertension and the use of total cholesterol levels to define hypercholesterolemia. These will be investigated and discussed in more detail during the data analysis phase of the study. It is also important to note that evidence maps describe the state of the evidence at a specific point in time, and therefore need to be updated regularly to reflect the latest practice; this should take place at least every 3 years, but annually may be preferable in rapidly evolving areas.¹⁶

Implementation of NCD policies change over time,⁷⁰ and this may impact on indices that are measured. Therefore, an analysis including MAPS needs to be refreshed periodically to consider longitudinal time trends in data.

Conclusion

The burden of NCDs comes with a high human and economic cost, especially in LMICs. Patient journey data generated by the proposed study will represent the first comprehensive analysis from these regions. The goal is that a better understanding of the patient journey and specific local data will contribute to evidence-based, high-quality, and affordable advances in the management of NCDs. When applied at touchpoints along the patient journey, "beyond-the-pill" solutions can improve awareness to engage patients better, and to predict and prevent risk factors that lead to adverse health consequences. MAPS will permit a clearer understanding of patient journeys and allow better integration of patients into the healthcare system as decision makers, thus navigating the system with more confidence and achieving better outcomes.

Acknowledgments

Editorial and medical writing support were provided by Nicola Ryan, an independent medical writer, funded by Pfizer.

Disclosure

No author received an honorarium for the preparation of the article. Pai-Hui Huang, Barrett Jeffers and Kannan Subramaniam are current employees of Viatris Inc and were previously employed at Upjohn Division, Pfizer Ltd. Tanaya Bharatan and Kaveri Sidhu are employees of Pfizer Ltd. Dr. Peter Lansberg has received consultancy and speaker honorarium payments from Pfizer, Amgen, and Sanofi. The remaining authors have no conflicts of interest to declare. The views and opinions expressed in this article are those of the authors. They do not represent or reflect in any way the official policy or position of their current or previous employers. The authors report no other conflicts of interest in this work.