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© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

In addition to essential micronutrients such as vitamin C, citrus fruits represent a considerably rich source of non-essential bioactive compounds, particularly flavanones which form a sub-set of the flavonoids group. Preclinical studies have highlighted the neuroprotective potential of citrus flavonoids, with well-established anti-oxidative, anti-inflammatory and newly emerging blood-brain barrier function/integrity mechanistic actions providing an explanation for their potential in modifying risk of neurological disease. Encouragingly, results from human studies, although limited in number, appear to support this preclinical basis, with improvements in cognitive performance and disease risk observed across healthy and disease states. Therefore, citrus fruits – both as whole fruit and 100% juices - should be encouraged within the diet for their potential neurological benefit. In addition, there should be further exploration of citrus polyphenols to establish therapeutic efficacy, particularly in the context of well-designed human interventions.

Details

Title
Citrus Polyphenols in Brain Health and Disease: Current Perspectives
Author
Pontifex, Matthew G; Malik, Mohammad M. A. H.; Connell, Emily; Müller, Michael; Vauzour, David
Section
Review ARTICLE
Publication year
2021
Publication date
Feb 19, 2021
Publisher
Frontiers Research Foundation
ISSN
16624548
e-ISSN
1662453X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2491437095
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.