Abstract

Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.

Details

Title
Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
Author
Laramie, Matthew D 1 ; Fouts, Benjamin L 2 ; MacCuaig, William M 3 ; Buabeng Emmanuel 4 ; Jones, Meredith A 5 ; Mukherjee Priyabrata 6 ; Behkam Bahareh 7 ; McNally, Lacey R 8 ; Henary Maged 4 

 Georgia State University, Department of Chemistry, Atlanta, USA (GRID:grid.256304.6) (ISNI:0000 0004 1936 7400) 
 Oklahoma Health Science Center, Department of Surgery, Oklahoma City, USA (GRID:grid.256304.6); Stephenson Cancer Center, Oklahoma Health Science Center, Oklahoma City, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018) 
 Stephenson Cancer Center, Oklahoma Health Science Center, Oklahoma City, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018); University of Oklahoma, Department of Biomedical Engineering, Norman, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018) 
 Georgia State University, Department of Chemistry, Atlanta, USA (GRID:grid.256304.6) (ISNI:0000 0004 1936 7400); Georgia State University, Center for Diagnostics and Therapeutics, Atlanta, USA (GRID:grid.256304.6) (ISNI:0000 0004 1936 7400) 
 University of Oklahoma, Department of Biomedical Engineering, Norman, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018) 
 Oklahoma Health Science Center, Department of Pathology, Oklahoma City, USA (GRID:grid.266900.b) 
 Virginia Tech University, Department of Mechanical Engineering, Blacksburg, USA (GRID:grid.438526.e) (ISNI:0000 0001 0694 4940) 
 Oklahoma Health Science Center, Department of Surgery, Oklahoma City, USA (GRID:grid.438526.e); Stephenson Cancer Center, Oklahoma Health Science Center, Oklahoma City, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018); University of Oklahoma, Department of Biomedical Engineering, Norman, USA (GRID:grid.266900.b) (ISNI:0000 0004 0447 0018); Wake Forest University, Department of Cancer Biology, Winston-Salem, USA (GRID:grid.241167.7) (ISNI:0000 0001 2185 3318) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2492469480
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.