It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Altered composition of gut bacteria and changes to the production of their bioactive metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of multiple sclerosis (MS). However, the immunomodulatory actions of SCFAs and intermediaries in their ability to influence MS pathogenesis are uncertain. In this study, levels of serum SCFAs were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome (CIS; an early form of MS) or MS and compared to healthy controls. There was a small but significant reduction in propionate levels in the serum of patients with CIS or MS compared with healthy controls. The frequencies of circulating T follicular regulatory cells and T follicular helper cells were significantly positively correlated with serum levels of propionate. Levels of butyrate associated positively with frequencies of IL-10-producing B-cells and negatively with frequencies of class-switched memory B-cells. TNF production by polyclonally-activated B-cells correlated negatively with acetate levels. Levels of serum SCFAs associated with changes in circulating immune cells and biomarkers implicated in the development of MS.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Telethon Kids Institute, University of Western Australia, West Perth, Australia (GRID:grid.414659.b) (ISNI:0000 0000 8828 1230); University of Western Australia, Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, Perth, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910)
2 Telethon Kids Institute, University of Western Australia, West Perth, Australia (GRID:grid.414659.b) (ISNI:0000 0000 8828 1230)
3 University of Sydney, Institute for Clinical Pathology and Medical Research, NSW Health Pathology and Westmead Institute for Medical Research, Centre for Immunology and Allergy Research, Westmead, Sydney, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X)
4 University of NSW, St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432)
5 University of Western Australia, Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, Perth, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910); Murdoch University, Institute for Immunology and Infectious Disease, Perth, Australia (GRID:grid.1025.6) (ISNI:0000 0004 0436 6763)
6 University of Western Australia, UWA Medical School and School of Biomedical Sciences, Perth, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910)
7 University of Western Australia, Medical School, Perth, Australia (GRID:grid.1012.2) (ISNI:0000 0004 1936 7910); Curtin University, School of Public Health, Curtin Health Innovation Research Institute, Perth, Australia (GRID:grid.1032.0) (ISNI:0000 0004 0375 4078)