Abstract

Purpose

To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target volume (TgV) as well as the influence that each modality has in the dosimetric calculation.

Methods

TgVs from 99mTc-MAA-SPECT/CT, CECT and CBCT were consecutively obtained in 24 patients treated with RE and compared with 90Y PET/CT TgV. Using the TgVs estimated by each imaging modality and a fictitious activity of 1 GBq, the corresponding absorbed doses by tumor and non-tumoral parenchyma were calculated for each patient. The absorbed doses for each modality were compared with the ones obtained using 90Y PET/CT TgV.

Results

99mTc-MAA-SPECT/CT predicted 90Y PET/CT TgV better than CBCT or CECT, even for selective or superselective administrations. Likewise, 99mTc-MAA-SPECT/CT showed dosimetric values more similar to those obtained with 90Y PET/CT. Nevertheless, CBCT provided essential information for RE planning, such as ensuring the total coverage of the tumor and, in cases with more than one feeding artery, splitting the activity according to the volume of tumor perfused by each artery.

Conclusion

The joint use of 99mTc-MAA-SPECT/CT and CBCT optimizes dosimetric planning for RE procedures, enabling a more accurate personalized approach.

Details

Title
The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning
Author
Rodríguez-Fraile Macarena 1   VIAFID ORCID Logo  ; Ezponda Ana 2 ; Grisanti Fabiana 1 ; Morán Verónica 3 ; Calvo, Marta 2 ; Berián Pablo 2 ; de la Cuesta Antonio Martínez 2 ; Sancho Lidia 4 ; Iñarrairaegui Mercedes 5 ; Sangro Bruno 5 ; Bilbao, José Ignacio 2 

1  Clínica Universidad de Navarra, Nuclear Medicine Department, Pamplona, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X) 
2  Clínica Universidad de Navarra, Radiology Department, Pamplona, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X) 
3  Clínica Universidad de Navarra, Medical Physics Department, Madrid, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X) 
4  Clínica Universidad de Navarra, Nuclear Medicine Department, Madrid, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X) 
5  Clínica Universidad de Navarra, Department of Internal Medicine-Hepatology, Pamplona, Spain (GRID:grid.411730.0) (ISNI:0000 0001 2191 685X) 
Publication year
2021
Publication date
Mar 2021
Publisher
Springer Nature B.V.
e-ISSN
2191219X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13550-021-00764-z
ProQuest document ID
2496272009
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.