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Abstract
In the present study, we investigated the pattern of changes in antibiotic prescription and antimicrobial resistance (AMR) in Escherichia coli in South Korea between 2007 and 2018. We collected data related to antibiotic prescription and AMR in E. coli from the national surveillance system. We used the Mann–Kendall test and Spearman’s correlation to identify the trends of antibiotic prescription and AMR in E. coli and to examine the relationship between them, respectively. Although we noted a significant decreasing trend of ampicillin and gentamicin prescriptions in all medical institutions, we identified a higher level of AMR in long-term care facilities than in other medical institutions. We did not identify a significant positive correlation between ampicillin and gentamicin prescriptions and their resistance in E. coli. However, we found a significant positive correlation between cefotaxime prescription and its resistance in E. coli in hospitals, long-term care facilities, and clinics. Our results strongly suggest that long-term care facilities in South Korea have the potential to sustain AMR epidemics and that more efforts are needed to curb AMR in E. coli. Further epidemiological studies using enhanced AMR surveillance are warranted.
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Details
1 Health Insurance Review and Assessment Service, Pharmaceutical and Medical Technology Research Team, Department of Research, Wonju, South Korea (GRID:grid.467842.b) (ISNI:0000 0004 0647 5429)
2 Konyang University College of Medicine, Department of Preventive Medicine, Daejeon, South Korea (GRID:grid.411143.2) (ISNI:0000 0000 8674 9741)
3 Korean Centers for Disease Control and Prevention, National Institute of Health, Osong, South Korea (GRID:grid.418967.5) (ISNI:0000 0004 1763 8617)