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© 2021 Talyansky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Triple depletion of macrophages, neutrophils, and complement induced the conversion of a hypovirulent, rapidly-cleared strain (ATCC 17978) into a hypervirulent strain capable of in vivo lethality similar to a hypervirulent clinical isolate (HUMC1) [7]. [...]escape from innate immune effectors is a key driver of A. baumannii virulence. First was the presence of an extra gene (pgt1) near the end of the capsule locus in the KL22 type strain (HUMC1), and not in the KL3 strain (ATCC 17978). [...]was a transposon insertion near the end of the gtr6 coding region resulting in a truncated mRNA sequence in the hypervirulent strain, HUMC1 (Fig 1A). All strains used in this study are described according to Kenyon classification capsule assembly locus type, genotype by gtr6 and pgt1, and relative phagocytic potential.:: = chromosomal gene insertion, / = plasmid insertion, * = generated mutant. https://doi.org/10.1371/journal.ppat.1009291.t001 When these two differences between HUMC1 and ATCC 17978 capsule loci were evaluated in other KL22- and KL3-type strains, we found that strains with intact gtr6 genes were readily phagocytosed [12] (Table 1).

Details

Title
Capsule carbohydrate structure determines virulence in Acinetobacter baumannii
Author
Talyansky, Yuli  VIAFID ORCID Logo  ; Nielsen, Travis B  VIAFID ORCID Logo  ; Yan, Jun  VIAFID ORCID Logo  ; Carlino-Macdonald, Ulrike  VIAFID ORCID Logo  ; Gisela Di Venanzio  VIAFID ORCID Logo  ; Chakravorty, Somnath; Ulhaq, Amber  VIAFID ORCID Logo  ; Feldman, Mario F  VIAFID ORCID Logo  ; Russo, Thomas A  VIAFID ORCID Logo  ; Vinogradov, Evgeny  VIAFID ORCID Logo  ; Luna, Brian  VIAFID ORCID Logo  ; Wright, Meredith S; Adams, Mark D  VIAFID ORCID Logo  ; Spellberg, Brad
First page
e1009291
Section
Research Article
Publication year
2021
Publication date
Feb 2021
Publisher
Public Library of Science
ISSN
15537366
e-ISSN
15537374
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2501883539
Copyright
© 2021 Talyansky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.