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© 2021 Kruglikov, Scherer. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

[...]the age-adjusted levels of LPS significantly vary in different ethnic groups, being the highest in South Asians. [...]a “leaky gut” condition can be induced by SARS-CoV-2 infection in seemingly non-compromised individuals as well. [...]we have to differentiate between the “preexisting” and “induced” endotoxemia in COVID-19 patients. Amino acids are strongly involved in the regulation of the intestinal epithelial barrier function [19]; hence, a reduction of ACE2 content induced by interactions of these receptors with SARS-CoV-2 will significantly impair the integrity of the intestinal barrier. [...]it was reported that ACE2 exhibits a protective effect against LPS-induced acute lung injury in mice [21]; hence, viral suppression of ACE2 can lead to a stronger inflammatory responses in lungs.

Details

Title
Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes
Author
Kruglikov, Ilja L  VIAFID ORCID Logo  ; Scherer, Philipp E  VIAFID ORCID Logo 
First page
e1009306
Section
Opinion
Publication year
2021
Publication date
Feb 2021
Publisher
Public Library of Science
ISSN
15537366
e-ISSN
15537374
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2501883562
Copyright
© 2021 Kruglikov, Scherer. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.