Abstract

[...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day) together with lifestyle modifications. [2] Given that patients with 6q24-related TNDM have relatively healthy beta cell function at remission, sulfonylurea treatment has a biological rationale in patients with 6q24-related TNDM, as its potential mechanisms are: (1) patients with 6q24-related TNDM presumably have intact sulfonylurea receptors at the pancreatic ß-cell and (2) the beta cells of patients with 6q24-related TNDM have decreased sensitivity to glucose, so sulfonylurea helps to improve the release of insulin.

Details

Title
Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea
Author
Jun-Ling, Fu; Wang, Tong; Xin-Hua, Xiao
Pages
846-848
Section
Correspondence
Publication year
2019
Publication date
Apr 2019
Publisher
Lippincott Williams & Wilkins Ovid Technologies
ISSN
03666999
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2502604028
Copyright
Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.