Abstract
[1] In clinical practices, P-PEAC is easily confused with secondary pulmonary enteric adenocarcinoma (S-PEAC) that is manifested as pulmonary infiltration onset. [...]a retrospective study was carried out to investigate the difference of clinical manifestation, imaging presentation, immunohistochemical staining, and molecular pathological characteristics of P-PEAC and S-PEAC. P-PEACs shared some morphologic and immunohistochemical appearances with pulmonary adenocarcinoma and S-PEAC, thereby making the differential diagnosis between P-PEACs and S-PEAC challenging. [...]histologic subtyping can be used to distinguish P-PEAC from S-PEAC, which is essentially intrapulmonary metastasis. Apart from medical history, clinical manifestations, laboratory tests, physical examinations and histopathology, immunohistochemistry, and KRAS mutations status serve as more important identifying points. [...]studies are required to improve our understanding of driver gene mutations-related targeted therapy and standard chemotherapy regimen.
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Details
1 Graduate College of Fujian Medical University, Fuzhou, Fujian 350025, China
2 Pathology Department, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army, Fujian Medical University, Fuzhou, Fujian 350025, China
3 Department of Respiratory and Critical Care Medicine, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army, Fujian Medical University, Fuzhou, Fujian 350025, China
4 Respiratory Department, Zhangzhou Zhengxing Hospital, Zhangzhou, Fujian 363000, China
5 Medical Imaging Center, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army, Fujian Medical University, Fuzhou, Fujian 350025, China