Abstract
[3] However, the role of PD-L1-expressing neutrophils has not been investigated in PCP. [...]the purpose of the present study was to examine the expression of PD-L1 on circulating neutrophils and to evaluate their clinical relevance in patients with PCP. [...]the number of activated neutrophils, which are the predominant subset with high PD-L1 expression, correlated with the overexpression of PD-1 on CD4+ T cells. [...]we speculate that the role of neutrophils is likely to modulate the immunosuppressive function of T cells in patients with PCP. [...]we did not store neutrophils derived from blood during our study due to their short lifespan. [...]the mechanism by which PD-L1-expressing neutrophils regulate T cell function in patients with PCP requires further investigation.
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Details
1 Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
2 Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China
3 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
4 Beijing Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China