Microfragmented adipose tissue and its initial application in articular disease

Abstract

Compared with the SVF, the MAT contains more angiogenic growth factors, such as angiogenin, endoglin, dipeptidyl peptidase IV, hepatocyte growth factor, placenta growth factor, and other cytokines such as adiponectin, CD14, CD31, insulin-like growth factor binding protein 2, and complement D.[6,17] These secretions cannot only help to repair tissues but also have anti-inflammatory effects. [...]MAT maintains the intact stromal vascular niche, can help to repair damaged areas, and reduces inflammatory responses through the secretory ability of the niches. According to the follow-up results, MAT injection can reduce pain and improve joint function. Approximately six months after the MAT injection, his VAS score was increased from 8 to 0 and MRI showed that the articular cartilage had expanded the joint space from 0.75 to 1.50 mm. The MRI results showed that MAT could provide support, buffer and fill the soft tissue and had