A PET imaging study of the brain changes of glucose metabolism in patients with temporal lobe epilepsy and depressive disorder

Abstract

Background

This study aims to compare the difference of the brain changes of glucose metabolism between temporal lobe epilepsy patients (TLE) with major depressive disorder and temporal TLE without major depressive disorder.

Methods

A total of 24 TLE patients, who met the inclusion criteria of our hospital, were enrolled in this study. They were divided into a TLE with depression group (n = 11) and a TLE without depression group (n = 13), according to the results of the HAMD-24 Scale. Two groups patients were examined using ¹⁸F-FDG PET brain imaging.

Results

The low metabolic regions of the TLE with depression group were mainly found in the left frontal lobe, temporal lobe and fusiform gyrus, while the high metabolic regions of the TLE with depression group were mainly located in the right frontal lobe, visual joint cortex and superior posterior cingulate cortex. Both of the TLE groups had high metabolic compensation in the non-epileptic area during the interictal period.

Conclusions

There is an uptake difference of ¹⁸F-FDG between TLE patients with depression and TLE patients without depression in multiple encephalic regions.