Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk

Abstract

[...]gene expression analysis (i.e., gene expression profiling [GEP] and preferentially expressed antigen in melanoma [PRAME] status) after direct surgical tumor sampling has enhanced prognostic accuracy [3,4,5]. Taken together, these results identified potential vitreous proteins that correlate with gene expression patterns for UM metastatic risk. Proteomic changes in plasma are dynamic and may represent a variety of unrelated systemic changes. [...]verification in a larger cohort is required. Conclusions Vitreous biopsies can be used to identify candidate biomarkers for UM. [...]proteomic profiles can suggest biologically plausible mechanisms for tumor proliferation and suggest rational approaches for adjuvant therapy and metastatic risk surveillance.