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Copyright © 2021 Øyvind Bruserud et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused by widely different disorders including acute and chronic infections, neoplastic disorders, and inflammatory noninfectious disorders. In this case report, we present a 67-year-old male patient with hemorrhagic shock caused by an acute bleeding from the splenic artery. The patient was massively transfused with blood products and fluids and underwent laparotomy for hemostatic control and clinical stabilization. Multiorgan involvement by amyloid light-chain amyloidosis (AL-amyloidosis) caused by plasma cell dyscrasia, specifically with infiltration of the spleen artery, was found to be the underlying cause of his life-threatening bleeding. Based on this case, we discuss the features of serious spleen bleeding, massive transfusion therapy in the intensive care setting, and AL-amyloidosis pathophysiology and treatment.

Details

Title
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
Author
Bruserud, Øyvind 1 ; Tor Henrik Anderson Tvedt 2 ; Ahmed, Aymen Bushra 2 ; Olav Karsten Vintermyr 3 ; Hervig, Tor 4 ; Guttormsen, Anne Berit 5 ; Reikvam, Håkon 6   VIAFID ORCID Logo 

 Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway 
 Department of Medicine, Haukeland University Hospital, Bergen, Norway 
 Department of Pathology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway 
 Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Immunology and Transfusion Medicine, Haugesund Hospital, Norway 
 Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway 
 Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway 
Editor
Chiara Lazzeri
Publication year
2021
Publication date
2021
Publisher
John Wiley & Sons, Inc.
ISSN
20906420
e-ISSN
20906439
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2503352108
Copyright
Copyright © 2021 Øyvind Bruserud et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/