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Abstract
The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.
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Details
1 Northeast Agricultural University, Department of Veterinary Clinic, College of Veterinary Medicine, Harbin, People’s Republic of China (GRID:grid.412243.2) (ISNI:0000 0004 1760 1136)
2 Henan University of Animal Husbandry and Economy, College of Veterinary Medicine, Zhengzhou, People’s Republic of China (GRID:grid.256922.8) (ISNI:0000 0000 9139 560X)
3 Heilongjiang Academy of Agricultural Sciences, Branch of Animal Husbandry and Veterinary, Qiqihar, People’s Republic of China (GRID:grid.256922.8)