Abstract

Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.

Details

Title
Pyroptosis: mechanisms and diseases
Author
Pian, Yu 1 ; Zhang, Xu 1 ; Liu, Nian 1 ; Tang, Ling 1 ; Peng Cong 1 ; Chen, Xiang 1   VIAFID ORCID Logo 

1  Central South University, The Department of Dermatology, Xiangya Hospital, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164); National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615); Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615); Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615); Central South University, Xiangya Clinical Research Center for Cancer Immunotherapy, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
ISSN
20959907
e-ISSN
20593635
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41392-021-00507-5
ProQuest document ID
2506115471
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.