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Abstract
To describe the surgical outcomes of using human amniotic membrane (hAM) grafts in the management of retinal breaks in diabetic tractional detachment (TRD) and combined tractional and rhegmatogenous retinal detachment (CTRRD). A retrospective case series of 10 eyes with TRD or CTRRD receiving pars plana vitrectomy with hAM grafts implantation, compared with 13 controls receiving the same surgery without hAM grafts. Best-corrected visual acuity (BCVA) and re-detachment rate were compared between two groups. Postoperatively, all eyes in the hAM group had retina attachment without recurrence, while 9 eyes in the control group had retina re-detachment and required additional surgery (0% vs 69.2%, p = 0.003). The BCVA significantly improved in the hAM group (from 1.96 ± 0.95 to 1.44 ± 0.77 in log MAR, p = 0.03), but not improved in control group (p = 0.20). Postoperative optical coherence tomography of the eyes receiving hAM grafts demonstrated glial tissue regeneration and restoration of ellipsoid zone. In diabetic TRD or CTRRD, hAM grafts could be an effective method, with promising outcome. Compared to standard surgery, it could result in higher retina reattachment rate and significant visual improvement. Moreover, it may offer the adjunctive benefit in tissue regeneration and fasten ellipsoid zone restoration.
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Details
1 Changhua Christian Hospital, Department of Ophthalmology, Changhua City, Taiwan (GRID:grid.413814.b) (ISNI:0000 0004 0572 7372); Yunlin Christian Hospital, Department of Ophthalmology, Xiluo, Taiwan (GRID:grid.413814.b); Central Taiwan University of Science and Technology, Department of Optometry, Taichung City, Taiwan (GRID:grid.411043.3) (ISNI:0000 0004 0639 2818)
2 Changhua Christian Hospital, Department of Ophthalmology, Changhua City, Taiwan (GRID:grid.413814.b) (ISNI:0000 0004 0572 7372); Chung-Shan Medical University, School of Medicine, Taichung, Taiwan (GRID:grid.411641.7) (ISNI:0000 0004 0532 2041); Kaohsiung Medical University, School of Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); Da-Yeh University, Department of Optometry, Changhua, Taiwan (GRID:grid.445025.2)