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Abstract
The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood. Here, we examined the expression and function of ALKBH4 in non-small-cell lung cancer (NSCLC) and found that ALKBH4 was highly expressed in NSCLC, as compared to that in adjacent normal lung tissues. ALKBH4 knockdown significantly induced the downregulation of NSCLC cell proliferation via cell cycle arrest at the G1 phase of in vivo tumour growth. ALKBH4 knockdown downregulated E2F transcription factor 1 (E2F1) and its target gene expression in NSCLC cells. ALKBH4 and E2F1 expression was significantly correlated in NSCLC clinical specimens. Moreover, patients with high ALKBH4 expression showed a poor prognosis, suggesting that ALKBH4 plays a pivotal tumour-promoting role in NSCLC.
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1 Osaka University, Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)
2 Kagoshima University, Department of General Thoracic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima, Japan (GRID:grid.258333.c) (ISNI:0000 0001 1167 1801)
3 Kagoshima University, Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima, Japan (GRID:grid.258333.c) (ISNI:0000 0001 1167 1801)
4 Kagoshima University Graduate School of Medical and Dental Sciences, Human Pathology, Kagoshima City, Japan (GRID:grid.258333.c) (ISNI:0000 0001 1167 1801)