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Abstract
This study examines if overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms, and if these variables could be modified after 1 year of a multimodal intervention (diet, physical activity, psychosocial support). 342 adults (55–75 years) with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus Cognition study were randomized to the intervention or to the control group (lifestyle recommendations). Cognitive and psychopathological assessments were performed at baseline and after 1-year follow-up. At baseline, higher impulsivity was linked to higher food addiction and depressive symptoms, but not to body mass index (BMI). Food addiction not only predicted higher BMI and depressive symptoms, but also achieved a mediational role between impulsivity and BMI/depressive symptoms. After 1 year, patients in both groups reported significant decreases in BMI, food addiction and impulsivity. BMI reduction and impulsivity improvements were higher in the intervention group. Higher BMI decrease was achieved in individuals with lower impulsivity. Higher scores in food addiction were also related to greater post-treatment impulsivity. To conclude, overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms in mid/old age individuals with MetS. Our results also highlight the modifiable nature of the studied variables and the interest of promoting multimodal interventions within this population.
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1 Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Addictive Behaviours Unit, Department of Psychiatry, Barcelona, Spain (GRID:grid.413396.a) (ISNI:0000 0004 1768 8905); University Hospital of Bellvitge-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
2 University Hospital of Bellvitge-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427)
3 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Integrative Pharmacology and Neurosciences Systems, Barcelona, Spain (GRID:grid.20522.37) (ISNI:0000 0004 1767 9005)
4 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, Universitat Rovira i Virgili, Reus, Spain (GRID:grid.410367.7) (ISNI:0000 0001 2284 9230); Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain (GRID:grid.420268.a) (ISNI:0000 0004 4904 3503); Universitat Rovira i Virgili (URV), Serra Hunter Fellow, Reus, Spain (GRID:grid.410367.7) (ISNI:0000 0001 2284 9230)
5 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); University Hospital of Bellvitge, Lipids and Vascular Risk Unit, Internal Medicine, Hospitalet de Llobregat, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780)
6 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); University of Valencia, Department of Preventive Medicine, Valencia, Spain (GRID:grid.5338.d) (ISNI:0000 0001 2173 938X)
7 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Universitat Autònoma de Barcelona, Departament de Psicobiologia i Metodologia, Cerdanyola del Vallès, Barcelona, Spain (GRID:grid.7080.f)
8 University Hospital of Bellvitge-IDIBELL, Department of Psychiatry, Barcelona, Spain (GRID:grid.411129.e) (ISNI:0000 0000 8836 0780); Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); University of Barcelona, Department of Clinical Sciences, School of Medicine and Health Sciences, Hospitalet de Llobregat, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
9 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, Universitat Rovira i Virgili, Reus, Spain (GRID:grid.410367.7) (ISNI:0000 0001 2284 9230); Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain (GRID:grid.420268.a) (ISNI:0000 0004 4904 3503)
10 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, Universitat Rovira i Virgili, Reus, Spain (GRID:grid.410367.7) (ISNI:0000 0001 2284 9230); Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain (GRID:grid.420268.a) (ISNI:0000 0004 4904 3503); University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain (GRID:grid.411136.0) (ISNI:0000 0004 1765 529X)
11 Instituto de Salud Carlos III (ISCIII), Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Integrative Pharmacology and Neurosciences Systems, Barcelona, Spain (GRID:grid.20522.37) (ISNI:0000 0004 1767 9005); Experimentals i de la Salut Universitat Pompeu Fabra (CEXS-UPF), Departament de Ciències, Barcelona, Spain (GRID:grid.5612.0) (ISNI:0000 0001 2172 2676)




