It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Intracerebral haemorrhage (ICH) is a life-threatening emergency, the incidence of which has increased in part due to an increase in the use of oral anticoagulants. A blood-fluid level within the haematoma, as revealed by computed tomography (CT), has been suggested as a marker for oral anticoagulant-associated ICH (OAC-ICH), but the diagnostic specificity and prognostic value of this finding remains unclear. In 855 patients with CT-confirmed acute ICH scanned within 48 h of symptom onset, we investigated the sensitivity and specificity of the presence of a CT-defined blood-fluid level (rated blinded to anticoagulant status) for identifying concomitant anticoagulant use. We also investigated the association of the presence of a blood-fluid level with six-month case fatality. Eighteen patients (2.1%) had a blood-fluid level identified on CT; of those with a blood-fluid level, 15 (83.3%) were taking anticoagulants. The specificity of blood-fluid level for OAC-ICH was 99.4%; the sensitivity was 4.2%. We could not detect an association between the presence of a blood-fluid level and an increased risk of death at six months (OR = 1.21, 95% CI 0.28–3.88, p = 0.769). The presence of a blood-fluid level should alert clinicians to the possibility of OAC-ICH, but absence of a blood-fluid level is not useful in excluding OAC-ICH.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 King Abdulaziz University, Physiology Department, Faculty of Medicine, Jeddah, Saudi Arabia (GRID:grid.412125.1) (ISNI:0000 0001 0619 1117); UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Department of Brain Repair and Rehabilitation, UCL Stroke Research Centre, London, UK (GRID:grid.436283.8) (ISNI:0000 0004 0612 2631)
2 UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Department of Brain Repair and Rehabilitation, UCL Stroke Research Centre, London, UK (GRID:grid.436283.8) (ISNI:0000 0004 0612 2631)
3 University College London, Department of Statistical Science, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
4 University College London, Haemostasis Research Unit, Department of Haematology, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
5 UCL Institute of Neurology, Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
6 University of Edinburgh, Centre for Clinical Brain Sciences, School of Clinical Sciences, Edinburgh, UK (GRID:grid.4305.2) (ISNI:0000 0004 1936 7988)
7 University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool Centre for Cardiovascular Science, Liverpool, UK (GRID:grid.415992.2) (ISNI:0000 0004 0398 7066); Aalborg University, Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg, Denmark (GRID:grid.5117.2) (ISNI:0000 0001 0742 471X)
8 UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Department of Molecular Neuroscience, London, UK (GRID:grid.436283.8) (ISNI:0000 0004 0612 2631)
9 University of Glasgow, Queen Elizabeth University Hospital, Institute of Neuroscience and Psychology, Glasgow, UK (GRID:grid.8756.c) (ISNI:0000 0001 2193 314X)