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Abstract
The present study aimed to investigate whether the serum biomarkers of immune response orchestrate the seroconversion status in patients with autoimmune diseases (AID) upon planned primary 17DD-YF vaccination. For this purpose a total of 161 individuals were enrolled in a prospective study, including patients with Rheumatoid Arthritis (RA = 38), Spondyloarthritis (SpA = 51), Systemic Lupus Erythematosus (SLE = 21) and Sjögren’s Syndrome (SS = 30) along with a group of healthy controls (HC = 21). Analysis of plaque reduction neutralization test (PRNT) titers and seropositivity rates along with the 17DD-YF viremia and serum biomarkers were carried out at distinct time points (D0/D3–4/D5–6/D7/D14–28). The results demonstrated an overall lower PRNT titer and seropositivity rate (170 vs. 448; 77 vs. 95%) in AID as compared to HC, especially in SpA and SLE subgroups. No significant differences were observed in the viremia levels amongst groups. In general, a more prominent serum biomarker response was observed in AID as compared to HC, throughout the timeline kinetics. Remarkably, AID/PRNT(−) exhibited higher levels of several biomarkers at baseline as compared to AID/PRNT+. Moreover, while AID/PRNT(+) exhibited earlier increase in serum biomarkers at D3–4/D5–6, the AID/PRNT(−) displayed higher response at later time points (D7/D14–D28). Of note, a synchronic increase of IFN-γ at the peak of viremia (D5–6) was observed in HC and AID/PRNT(+) groups, whereas a later asynchronous IFN-γ response was reported for AID/PRNT(−) at D7. The biomarker profile tends to deflate at post-vaccination timeline, highlighting a putative immunomodulatory effect of live attenuated 17DD-YF vaccine in AID/PRNT(+), but not in AID/PRNT(−). Altogether these data suggested that inflammatory status prior vaccination, low IFN-γ at viremia peak and the occurrence of asynchronous biomarker storm after 17DD-YF vaccination may orchestrate the lack of neutralizing antibody response γ.
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Details
1 Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Grupo Integrado de Pesquisas Em Biomarcadores, Belo Horizonte, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931)
2 Hospital Universitário Cassiano Antônio de Moraes, Universidade Federal Do Espírito Santo (UFES), Vitória, Brazil (GRID:grid.412371.2) (ISNI:0000 0001 2167 4168)
3 Instituto de Tecnologia Em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil (GRID:grid.418068.3) (ISNI:0000 0001 0723 0931)
4 Hospital Universitário Cassiano Antônio de Moraes, Universidade Federal Do Espírito Santo (UFES), Vitória, Brazil (GRID:grid.412371.2) (ISNI:0000 0001 2167 4168); Escola de Ciências da Saúde da Santa Casa de Misericórdia, Vitória, Brazil (GRID:grid.412371.2)
5 Escola de Ciências da Saúde da Santa Casa de Misericórdia, Vitória, Brazil (GRID:grid.412371.2)
6 Centro de Referências Para Imunobiológicos Especiais (CRIE) da Secretaria de Saúde Do Estado Do Espírito Santo, Vitória, Brazil (GRID:grid.412371.2)
7 Secretaria de Vigilância Em Saúde, Ministério da Saúde, Departamento de Vigilância das Doenças Transmissíveis, Brasília, Brazil (GRID:grid.414596.b) (ISNI:0000 0004 0602 9808)
8 Faculdade de Ciências da Saúde de Barretos – FACISB, Barretos, Brazil (GRID:grid.414596.b)
9 Serviço de Reumatologia Do Hospital Universitário de Brasília, Universidade de Brasília, Programa de Pós Graduação Em Ciências Médicas, Faculdade de Medicina, Brasília, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157)