The Relationship Between Monocyte/HDL Cholesterol Ratio and Clinical Outcomes in Acute Myocarditis Patients

Abstract

Objectives:

Myocarditis is an inflammatory disease of the heart muscle. Inflammation and oxidative stress are known to play an important role in myocarditis pathogenesis. The aim of this study is to evaluate the relationship between clinical endpoints and monocyte/high-density lipoprotein (HDL) ratio in acute myocarditis patients.

Materials and Methods:

Between March 2009 and March 2017, 156 consecutive patients who underwent cardiac magnetic resonance with the diagnosis of acute myocarditis were included in the study. The patients were divided into two groups according to clinical endpoints. The clinical endpoint was defined as malignant arrhythmia, cardiovascular death during follow-up, and new-onset heart failure.

Results:

High C-reactive protein level, low high density lipoprotein cholesterol and glucose levels, and low ejection fraction were found in patients with clinical endpoints. (p<0.05 for all). Monocyte count, neutrophil count and the monocyte/HDL ratio (MHR) were significantly higher in the clinical endpoints group (p<0.05 for all). In multivariate logistic regression analysis, higher monocyte/HDL ratio (Odds ratio=1.213, confidence interval 95%=1.039-1.417, p=0.015) was found to be an independent predictor of clinical outcome in acute myocarditis.

Conclusion:

Consequently, this parameter can be used to predict prognosis and clinical outcomes with acute myocarditis patients.