Abstract

Background

The soluble prorenin receptor (sPRR), a member of the renin-angiotensin system (RAS), is elevated in plasma of patients with preeclampsia, hypertension, chronic kidney disease (CKD), and type 2 diabetes. Our goal was to examine the relationship between sPRR and RAS activation to define whether sexual dimorphisms in sPRR might explain sex disparities in renal outcomes in patients with type 2 diabetes.

Methods

Two hundred sixty-nine participants were included in the study (mean age, 48 ± 16 years; 42% men, 58% women), including 173 controls and 96 subjects with type 2 diabetes. In plasma and urine, we measured sPRR, plasma renin activity (PRA), and prorenin. In the urine, we also measured angiotensinogen along with other biomarkers of renal dysfunction.

Results

Plasma sPRR and PRA were significantly higher in women with type 2 diabetes compared to men. In these women, plasma sPRR was positively correlated with PRA, age, and body mass index (BMI). In contrast, in men the sPRR in urine but not in plasma positively correlated with eGFR in urine, but negatively correlated with urine renin activity, plasma glucose, age, and BMI.

Conclusions

In patients with type 2 diabetes, sPRR contributes to RAS stimulation in a sex-dependent fashion. In diabetic women, increased plasma sPRR parallels the activation of systemic RAS; while in diabetic men, decreased sPRR in urine matches intrarenal RAS stimulation. sPRR might be a potential indicator of intrarenal RAS activation and renal dysfunction in men and women with type 2 diabetes.

Details

Title
Sex differences in soluble prorenin receptor in patients with type 2 diabetes
Author
Visniauskas, Bruna; Arita, Danielle Y; Rosales, Carla B; Feroz, Mohammed A; Luffman, Christina; Accavitti, Michael J; Dawkins, Gabrielle; Hong, Jennifer; Curnow, Andrew C; Thethi, Tina K; Lefante, John J; Jaimes, Edgar A; Mauvais-Jarvis, Franck; Fonseca, Vivian A; Prieto, Minolfa C
Pages
1-12
Section
Research
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
20426410
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2528914961
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.