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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

[...]understanding better the mechanisms governing the cellular and molecular events that underlie the switch that precipitates the failure of the retina to respond adequately to oxidative and/or inflammatory insults may support the discovery of new therapeutic targets to prevent and treat irreversible vision loss and blindness. [...]dietary Se-Met supplementation could be a viable therapeutic strategy for retinal degenerative diseases. [...]it was reported that AMPK activation could exert cytoprotection by restoring mitochondrial respiration and reducing mitochondrial fission. Recently emerging shreds of evidence have highlighted an association between AMD and periodontal disease (PD); however, the underlying mechanisms are poorly understood [16]. [...]Arjunan et. al. set out to develop a simple, reproducible model that emulates characteristics of both AMD and PD [17].

Details

Title
Oxidative Stress and Inflammation in Retinal Degeneration
Author
Jadeja, Ravirajsinh N 1   VIAFID ORCID Logo  ; Martin, Pamela M 2 

 Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; [email protected] 
 Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; [email protected]; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA 
First page
790
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20763921
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2531379821
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.