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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.

Details

Title
The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
Author
Jun-O, Jin 1 ; Pallavi Singh Chauhan 2 ; Ananta Prasad Arukha 3 ; Chavda, Vishal 4 ; Dubey, Anuj 5 ; Yadav, Dhananjay 6   VIAFID ORCID Logo 

 Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea 
 Amity Institute of Biotechnology, Amity University Madhya Pradesh, Gwalior 474005, India; [email protected] 
 Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA; [email protected] 
 Division of Anaesthesia, Sardar Women’s Hospital, Ahmedabad 380004, Gujarat, India; [email protected] 
 Department of Chemistry, ITM Group of Institutions, Gwalior 475005, India; [email protected] 
 Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea 
First page
265
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
16603397
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2532169237
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.