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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Sequence type (ST) 131 is a multidrug-resistant pandemic lineage of E. coli responsible for extraintestinal infections. Few surveillance data of ST131 included all antimicrobial-susceptible and -resistant isolates or focused on community-acquired urinary tract infection (UTI). From a population-based surveillance pool of 2997 outpatient urine E. coli isolates, 542 were selected for detection of ST131 based on ciprofloxacin and/or cefotaxime resistance. Pulsed-field gel electrophoresis (PFGE) was performed on all ST131 isolates to further determine their relatedness. The estimated overall ST131 prevalence in this community UTI cohort increased from 11.2% (in 2002–2004), 12.2% (in 2006–2008), 13.6% (in 2010–2012), to 17.4% in 2014–2016 (p < 0.01). In the ciprofloxacin-resistant/cefotaxime-resistant group, ST131 increased from 33.3% in 2002–2004 to 72.1% in 2014–2016 (p < 0.01). In the ciprofloxacin-resistant/cefotaxime-susceptible group, ST131 was found in 24.3% overall without significant increase in its prevalence over time. PFGE showed emergence of a cluster of ciprofloxacin-resistant/cefotaxime-resistant ST131 carrying Gr. 1 CTX-M ESBL in 2014–2016, especially 2016. Multivariate analysis revealed that age (≥65 y.o) and ciprofloxacin resistance were independent factors associated with ST131. This longitudinal surveillance showed that ciprofloxacin-resistant/cefotaxime-susceptible ST131 has been circulating in the community since 2002 but ciprofloxacin-resistant/cefotaxime-resistant ST131 increased rapidly in the later years.

Details

Title
Temporal Trend of ST131 Clone among Urinary Escherichia coli Isolates in the Community: A Taiwan National Surveillance from 2002 to 2016
Author
Wang, Jiun-Ling 1   VIAFID ORCID Logo  ; Wen-Chien, Ko 1   VIAFID ORCID Logo  ; Hung, Chih-Hsin 2 ; Ming-Fang, Cheng 3 ; Hui-Ying, Wang 4 ; Shiau, Yih-Ru 4 ; Lai, Jui-Fen 4 ; I-Wen, Huang 4 ; Li-Yun, Hsieh 4 ; Tsai-Ling, Yang Lauderdale 4 ; Roberto Di Marco

 Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan; [email protected] (J.-L.W.); [email protected] (W.-C.K.); Department of Medicine, National Cheng Kung University, Tainan 704, Taiwan 
 Department of Chemical Engineering and Institute of Biotechnology and Chemical Engineering, Shou University, Kaohsiung 840, Taiwan; [email protected] (C.-H.H.); [email protected] (M.-F.C.) 
 Department of Chemical Engineering and Institute of Biotechnology and Chemical Engineering, Shou University, Kaohsiung 840, Taiwan; [email protected] (C.-H.H.); [email protected] (M.-F.C.); Department of Pediatrics, Kaohsiung Veterans General Hospital and School of Medicine, Kaohsiung 813, Taiwan; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan; Department of Nursing, Fooyin University, Kaohsiung 831, Taiwan 
 National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan 350, Taiwan; [email protected] (H.-Y.W.); [email protected] (Y.-R.S.); [email protected] (J.-F.L.); [email protected] (I.-W.H.); [email protected] (L.-Y.H.) 
First page
963
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20762607
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2532172181
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.