Full text

Turn on search term navigation

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Platinum-based antineoplastic drugs (PtADs) are among the most important and used families of chemotherapy drugs, which, even showing severe side effects and being hindered by drug resistance, are not likely to be replaced clinically any time soon. The growing interest in the occupational health community in antineoplastic drug (AD) surface contamination requires the development of increasingly fast and easy high-throughput monitoring methods, even considering the lack of harmonized legally binding regulation criteria. Thus, a wipe sampling method together with zwitterionic hydrophilic interaction liquid chromatography (HILIC-Z)–tandem mass spectrometry (MS/MS) analysis was developed for the simultaneous evaluation of oxaliplatin, cisplatin, and carboplatin surface contaminations. A design of experiments approach was used to optimize the chromatographic conditions. Limits of quantification ranging from 2 to 5 ng/mL were obtained from interday and intraday repetitions for oxaliplatin and carboplatin, and between 170 and 240 ng/mL for cisplatin. The wipe desorption procedure is equivalent to other AD sampling methods, enabling a fast sample preparation, with an LC-MS/MS analysis time of less than 7 min.

Details

Title
Characterization and Separation of Platinum-Based Antineoplastic Drugs by Zwitterionic Hydrophilic Interaction Liquid Chromatography (HILIC)–Tandem Mass Spectrometry, and Its Application in Surface Wipe Sampling
Author
Dugheri, Stefano 1   VIAFID ORCID Logo  ; Mucci, Nicola 2   VIAFID ORCID Logo  ; Mini, Enrico 3 ; Squillaci, Donato 2   VIAFID ORCID Logo  ; Marrubini, Giorgio 4   VIAFID ORCID Logo  ; Bartolucci, Gianluca 5   VIAFID ORCID Logo  ; Bucaletti, Elisabetta 2 ; Cappelli, Giovanni 2 ; Trevisani, Lucia 2 ; Arcangeli, Giulio 2 

 Industrial Hygiene and Toxicology Laboratory, Occupational Medicine Unit, Careggi University Hospital, 50134 Florence, Italy 
 Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy; [email protected] (N.M.); [email protected] (D.S.); [email protected] (E.B.); [email protected] (G.C.); [email protected] (L.T.); [email protected] (G.A.) 
 Department of Health Sciences, University of Florence, 50134 Florence, Italy; [email protected] 
 Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy; [email protected] 
 Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50019 Sesto Fiorentino, Italy; [email protected] 
First page
69
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
22978739
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2532387032
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.