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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The aim of this study was to determine whether self-collected pure saliva (SCPS) is comparable to nasopharyngeal (NP) swabs in the quantitative detection of SARS-CoV-2 by RT-PCR in asymptomatic, mild patients with confirmed COVID-19. Thirty-one patients aged from 18 to 85 years were included between 9 June and 11 December 2020. A SCPS sample and a NP sample were taken for each patient. Quantitative PCR was performed to detect SARS-CoV-2 viral load. Results of SCPS vs. NP samples testing were compared. Statistical analyses were performed. Viral load was significantly correlated (r = 0.72). The concordance probability was estimated at 73.3%. In symptomatic adults, SCPS performance was similar to that of NP swabs (Percent Agreement = 74.1%; p = 0.11). Thus, the salivary test based on pure oral saliva samples easily obtained by noninvasive techniques has a fair agreement with the nasopharyngeal one in asymptomatic, mild patients with a confirmed diagnosis of COVID-19.

Details

Title
Performance of Self-Collected Saliva Testing Compared with Nasopharyngeal Swab Testing for the Detection of SARS-CoV-2
Author
Carrouel, Florence 1   VIAFID ORCID Logo  ; Valette, Martine 2 ; Perrier, Hervé 3 ; Bouscambert-Duchamp, Maude 2 ; Dussart, Claude 1   VIAFID ORCID Logo  ; Tramini, Paul 4 ; Bourgeois, Denis 1   VIAFID ORCID Logo 

 Laboratory “Health Systemic Process”, EA4129, University Lyon 1, 69008 Lyon, France; [email protected] (C.D.); [email protected] (D.B.) 
 Virology Laboratory, Institute of Infectious Agents, Croix-Rousse Hospital, Hospices Civils of Lyon, 69004 Lyon, France; [email protected] (M.V.); [email protected] (M.B.-D.) 
 Clinical Research Unit, Protestant Infirmary, 69300 Caluire-et-Cuire, France; [email protected] 
 Department of Public Health, Faculty of Dental Medicine, University of Montpellier, 34090 Montpellier, France; [email protected] 
First page
895
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
19994915
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2532403534
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.