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Abstract
Marek’s disease virus (MDV) induces severe immunosuppression and lymphomagenesis in the chicken, its natural host, and results in a condition that investigated the pathogenesis of MDV and have begun to focus on the expression profiling of circular RNAs (circRNAs). However, little is known about how the expression of circRNAs is referred to as Marek’s disease. Previous reports have is regulated during MDV replication. Here, we carried out a comprehensive profiling analysis of N6-methyladenosine (m6A) modification on the circRNA transcriptome in infected and uninfected chicken embryonic fibroblast (CEF) cells. Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) revealed that m6A modification was highly conserved in circRNAs. Comparing to the uninfected group, the number of peaks and conserved motifs were not significantly different in cells that were infected with MDV, although reduced abundance of circRNA m6A modifications. However, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses revealed that the insulin signaling pathway was associated with the regulation of m6A modified circRNAs in MDV infection. This is the first report to describe alterations in the transcriptome-wide profiling of m6A modified circRNAs in MDV-infected CEF cells.
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1 Henan Agricultural University, College of Veterinary Medicine, Zhengzhou, People’s Republic of China (GRID:grid.108266.b) (ISNI:0000 0004 1803 0494); Henan Agricultural University, International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Zhengzhou, People’s Republic of China (GRID:grid.108266.b) (ISNI:0000 0004 1803 0494)
2 Henan Academy of Agricultural Sciences, Key Laboratory of Animal Immunology, Ministry of Agriculture and Rural Affairs and Henan Provincial Key La-boratory of Animal Immunology, Zhengzhou, People’s Republic of China (GRID:grid.495707.8) (ISNI:0000 0001 0627 4537); Henan Academy of Agricultural Sciences, UK-China Centre of Excellence for Research on Avian Diseases, Zhengzhou, People’s Republic of China (GRID:grid.495707.8) (ISNI:0000 0001 0627 4537)
3 Henan Academy of Agricultural Sciences, Key Laboratory of Animal Immunology, Ministry of Agriculture and Rural Affairs and Henan Provincial Key La-boratory of Animal Immunology, Zhengzhou, People’s Republic of China (GRID:grid.495707.8) (ISNI:0000 0001 0627 4537); Henan Academy of Agricultural Sciences, UK-China Centre of Excellence for Research on Avian Diseases, Zhengzhou, People’s Republic of China (GRID:grid.495707.8) (ISNI:0000 0001 0627 4537); Henan University of Science and Technology, College of Animal Science and Technology, Luoyang, People’s Republic of China (GRID:grid.453074.1) (ISNI:0000 0000 9797 0900)
4 Henan Agricultural University, College of Veterinary Medicine, Zhengzhou, People’s Republic of China (GRID:grid.108266.b) (ISNI:0000 0004 1803 0494); Henan Agricultural University, International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Zhengzhou, People’s Republic of China (GRID:grid.108266.b) (ISNI:0000 0004 1803 0494); Henan Academy of Agricultural Sciences, Key Laboratory of Animal Immunology, Ministry of Agriculture and Rural Affairs and Henan Provincial Key La-boratory of Animal Immunology, Zhengzhou, People’s Republic of China (GRID:grid.495707.8) (ISNI:0000 0001 0627 4537)