Abstract

Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.

Details

Title
Highly dampened blood transcriptome response in HIV patients after respiratory infection
Author
Sellers, Subhashini A 1 ; Fischer, William A, II 1 ; Heise, Mark T 2 ; Schughart Klaus 3   VIAFID ORCID Logo 

1  University of North Carolina at Chapel Hill, Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208) 
2  University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208); University of North Carolina at Chapel Hill, Department of Microbiology and Immunology, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000000122483208); University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, USA (GRID:grid.410711.2) (ISNI:0000 0001 1034 1720) 
3  Helmholtz Centre for Infection Research, Department of Infection Genetics, Brunswick, Germany (GRID:grid.7490.a) (ISNI:0000 0001 2238 295X); University of Veterinary Medicine Hannover, Hannover, Germany (GRID:grid.412970.9) (ISNI:0000 0001 0126 6191); University of Tennessee Health Science Center, Department of Microbiology, Immunology and Biochemistry, Memphis, USA (GRID:grid.267301.1) (ISNI:0000 0004 0386 9246) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-021-83876-9
ProQuest document ID
2534802937
Copyright
© The Author(s) 2021. corrected publication 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.