Abstract

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. A strong inverse correlation between miR-21-5p and KRIT1 expression levels was observed in CRC-adjacent vessels. Furthermore, miR-21-5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. Thus, our data suggest that exosomal miR-21-5p is involved in angiogenesis and vascular permeability in CRC and may be used as a potential new therapeutic target.

Details

Title
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1
Author
He Qinglian 1 ; Ye Aihua 2 ; Ye Weibiao 3 ; Liao Xiaomin 3 ; Qin Guoqiang 4 ; Xu, Yongqiang 3 ; Yin Yuting 5 ; Luo Huanqian 6 ; Muhua, Yi 3 ; Xian Liying 3 ; Zhang Shihao 3 ; Qin Xiyuan 3 ; Zhu, Wei 5 ; Li, Yuling 3   VIAFID ORCID Logo 

1  Dongguan People’s Hospital affiliated to Southern Medical University, Department of Pathology, Dongguan, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471); Guangdong Medical University, Department of Pathology, Dongguan, China (GRID:grid.410560.6) (ISNI:0000 0004 1760 3078) 
2  Longhua District Maternity and Child Healthcare Hospital, Department of Obstetrics, Shenzhen, China (GRID:grid.410560.6) 
3  Dongguan People’s Hospital affiliated to Southern Medical University, Department of Pathology, Dongguan, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
4  Dongguan People’s Hospital affiliated to Southern Medical University, Department of science and education, Dongguan, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
5  Guangdong Medical University, Department of Pathology, Dongguan, China (GRID:grid.410560.6) (ISNI:0000 0004 1760 3078) 
6  Dongguan People’s Hospital affiliated to Southern Medical University, Department of Ultrasound, Dongguan, China (GRID:grid.284723.8) (ISNI:0000 0000 8877 7471) 
Publication year
2021
Publication date
Jun 2021
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-021-03803-8
ProQuest document ID
2537005507
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.