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© 2021 Xin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Results from studies have suggested that the NF-kB gene plays a role in the occurrence of lung cancer, colorectal cancer, breast cancer, and other cancers [15–18]. According to the Preferred Practice Pattern Guidelines: Age-related Macular Degeneration [25] and the “Chinese clinical diagnosis and treatment pathway for age-related macular degeneration” [26], AMD was diagnosed when the presence of one or more of the following criteria was met: 1) medium-sized hyaline warts (>63 μm in diameter); 2) RPE abnormalities such as hypopigmentation, pigment proliferation, migration, and metaplasia; and 3) any of the following characteristics: retinal pigment epithelium map atrophy, choroidal neovascularization (exudative), polypoid choroidal vasculopathy, and retinal hemangioma hyperplasia. Demographic and clinical features of patients with AMD and controls. https://doi.org/10.1371/journal.pone.0251931.t002 Genotype distributions of NF-kB gene polymorphisms in patients with AMD and controls Genotype distributions of all four SNPs followed Hardy-Weinberg equilibrium in the control group (P > 0.05). Genotype distributions of NF-kB gene polymorphisms in patients with AMD and controls. https://doi.org/10.1371/journal.pone.0251931.t004 Discussion AMD is a complex, highly inherited multifactorial disease caused by the interaction of genetic and environmental risk factors [28].

Details

Title
Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population
Author
Yan, Xin; Kang Zefeng; Li, Ling; Guan Ruijuan
First page
e0251931
Section
Research Article
Publication year
2021
Publication date
Jun 2021
Publisher
Public Library of Science
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2539284878
Copyright
© 2021 Xin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.