Abstract

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus.

Video Abstract

Details

Title
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Author
Lu, Juane; Wu, Tao; Zhang, Biao; Liu, Suke; Song, Wenjun; Qiao, Jianjun; Ruan, Haihua  VIAFID ORCID Logo 
Pages
1-10
Section
Review
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
1478811X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12964-021-00741-y
ProQuest document ID
2543468667
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.