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Abstract
The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.
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Details
1 Universidade de Brasília, Enzymology Laboratory, Department of Cell Biology, Distrito Federal, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157)
2 Faculdade de Medicina de São José do Rio Preto, Department of Dermatological, Infectious and Parasitic Disease, São Paulo, Brazil (GRID:grid.419029.7) (ISNI:0000 0004 0615 5265)
3 Universidade Federal de Jataí, Veterinary Laboratory, Institute of Agricultural Sciences, Goiás, Brazil (GRID:grid.419029.7)
4 Universidade Federal de Viçosa, Laboratory of Immunobiological and Animal Virology, Department of Veterinary, Minas Gerais, Brazil (GRID:grid.12799.34) (ISNI:0000 0000 8338 6359)
5 Universidade Federal de Jataí, Virology Laboratory, Institute of Health Sciences, Goiás, Brazil (GRID:grid.12799.34)