Prevalence of Atrial Fibrillation in Patients with Amyloidosis: Analysis from the National Inpatient Sample

Abstract

Objective: To identify the prevalence of atrial fibrillation in amyloidosis patients.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF is associated with an increased risk of stroke, heart failure, and mortality. Amyloidosis has become more incident recently due to the evolving laboratory and cardiac imaging modalities. Data is limited on the association between amyloid and AF.

Methods: This is a retrospective cohort study of patients with amyloidosis from the National Inpatient Sample (NIS) of the year 2014. The primary outcome was the diagnosis of AF in the amyloidosis vs. the non-amyloidosis population. Logistic regression models were used to assess predictors of AF among the study population.

Results: 5,872,587 health encounters from the NIS were identified. Of these, 4,287 subjects had a diagnosis of amyloidosis. AF was found in 28.7% of the amyloidosis vs. 13.4% % of the non-amyloidosis group, p < 0.001. Diabetes mellitus, hypertension, black ethnicity, and obesity were common in the amyloidosis group. On multivariate analysis, amyloidosis was a strong predictor of AF (OR 1.37 (95% CI 1.28–1.47, p < 0.001).

Conclusion: AF and amyloidosis are mutually associated identities. High suspicion should be maintained for the diagnosis of amyloidosis in patients presenting with AF.