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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Heart failure (HF) is a complicated clinical syndrome that is considered an increasingly frequent reason for hospitalization, characterized by a complex therapeutic regimen, reduced quality of life, and high morbidity. Long-standing hypertension ultimately paves the way for HF. Recently, there have been improvements in the treatment of hypertension and overall management not limited to only conventional medications, but several novel pathways and their pharmacological alteration are also conducive to the treatment of hypertension. Beta-arrestin (β-arrestin), a protein responsible for beta-adrenergic receptors’ (β-AR) functioning and trafficking, has recently been discovered as a potential regulator in hypertension. β-arrestin isoforms, namely β-arrestin1 and β-arrestin2, mainly regulate cardiac function. However, there have been some controversies regarding the function of the two β-arrestins in hypertension regarding HF. In the present review, we try to figure out the paradox between the roles of two isoforms of β-arrestin in the treatment of HF.

Details

Title
Beta-Arrestins in the Treatment of Heart Failure Related to Hypertension: A Comprehensive Review
Author
Rakib, Ahmed 1   VIAFID ORCID Logo  ; Taslima Akter Eva 1 ; Saad Ahmed Sami 1   VIAFID ORCID Logo  ; Mitra, Saikat 2 ; Iqbal Hossain Nafiz 3 ; Das, Ayan 3 ; Tareq, Abu Montakim 4   VIAFID ORCID Logo  ; Nainu, Firzan 5   VIAFID ORCID Logo  ; Dhama, Kuldeep 6   VIAFID ORCID Logo  ; Talha Bin Emran 7   VIAFID ORCID Logo  ; Simal-Gandara, Jesus 8   VIAFID ORCID Logo 

 Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh; [email protected] (A.R.); [email protected] (T.A.E.); [email protected] (S.A.S.) 
 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh; [email protected] 
 Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh; [email protected] (I.H.N.); [email protected] (A.D.) 
 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh; [email protected] 
 Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Kota Makassar, Sulawesi Selatan 90245, Indonesia; [email protected] 
 Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India; [email protected] 
 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh 
 Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo–Ourense Campus, E32004 Ourense, Spain 
First page
838
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
19994923
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2544933837
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.