Abstract

The COVID-19 pandemic has been a catalyst for the implementation of decentralized clinical trials (DCTs) enabled by digital health technologies (DHTs) in the field while curtailing in-person interactions and putting significant demands on health care resources. DHTs offer improvements in real-time data acquisition remotely while maintaining privacy and security. Here, we describe the implications of technologies, including edge computing, zero-trust environments, and federated computing in DCTs enabled by DHTs. Taken together, these technologies—in the setting of policy and regulation that enable their use while protecting the users—extend the scope and accelerate the pace of clinical research.

Details

Title
Empowering clinical research in a decentralized world
Author
De Brouwer Walter 1 ; Patel, Chirag J 2 ; Manrai, Arjun K 2 ; Rodriguez-Chavez, Isaac R 3   VIAFID ORCID Logo  ; Shah, Nirav R 4   VIAFID ORCID Logo 

1  Sharecare, Palo Alto, USA; Stanford University, Clinical Excellence Research Center, Department of Medicine, Palo Alto, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
2  XY.Health, Inc., Cambridge, USA (GRID:grid.168010.e) 
3  PRA Health Sciences, Charlottesville, USA (GRID:grid.419301.e) (ISNI:0000 0004 0467 423X) 
4  Sharecare, Palo Alto, USA (GRID:grid.419301.e); Stanford University, Clinical Excellence Research Center, Department of Medicine, Palo Alto, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
Publication year
2021
Publication date
Dec 2021
Publisher
Nature Publishing Group
e-ISSN
23986352
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41746-021-00473-w
ProQuest document ID
2547166471
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.