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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

Helicobacter pylori infection is associated with the development of gastric cancer. Reflux esophagitis may occur in the postoperative period of patients undergoing surgical therapy for gastric cancer. The role of eradication therapy of Helicobacter pylori in reflux esophagitis is controversial. Here, we evaluated the occurrence of reflux esophagitis before and after Helicobacter pylori eradication in patients having endoscopic submucosal resection for early gastric cancer. Reflux esophagitis before and after eradication therapy was evaluated during the follow-up. While reflux esophagitis incidence increased from 3.1% to 18.8% in the successful eradication group, no case of reflux esophagitis was observed in the failed eradication group. There was a significant correlation between successful Helicobacter pylori eradication rate and reflux esophagitis development. This study demonstrates that a successful Helicobacter pylori eradication therapy is a risk factor for newly developed reflux esophagitis in patients having endoscopic submucosal dissection for early gastric cancer.

Abstract

Background: The role of Helicobacter pylori in the pathogenesis of reflux esophagitis is controversial. This study investigated the frequency of reflux esophagitis before and after H. pylori eradication in patients having endoscopic submucosal dissection for early gastric cancer. Methods: This study included 160 patients that fulfilled the study’s criteria. Endoscopy was performed before and after H. pylori eradication, and reflux esophagitis was evaluated during the follow-up period. Results: Seropositivity for H. pylori in patients with early gastric cancer was 68.8%, 101 of them received eradication therapy. During the follow-up period, the incidence of reflux esophagitis increased from 3.1% to 18.8% in the successful eradication group but no case of reflux esophagitis was observed in the failed eradication group. The univariate and multivariate analyses showed a significant correlation between successful H. pylori eradication rate and the development of reflux esophagitis. Conclusions: This study demonstrated that a successful H. pylori eradication therapy is a risk factor for newly developed reflux esophagitis in patients with endoscopic submucosal dissection for early gastric cancer.

Details

Title
Increased Reflux Esophagitis after Helicobacter pylori Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer
Author
Katsurahara, Masaki 1   VIAFID ORCID Logo  ; Imoto, Ichiro 2 ; Umeda, Yuhei 3 ; Miura, Hiroshi 3 ; Tsuboi, Junya 3 ; Yamada, Reiko 3   VIAFID ORCID Logo  ; Yasuma, Taro 4 ; Nakamura, Misaki 3   VIAFID ORCID Logo  ; Hamada, Yasuhiko 3   VIAFID ORCID Logo  ; Inoue, Hiroyuki 3   VIAFID ORCID Logo  ; Tanaka, Kyosuke 1   VIAFID ORCID Logo  ; Horiki, Noriyuki 1 ; Gabazza, Esteban C 4   VIAFID ORCID Logo  ; Takei, Yoshiyuki 3 

 Department of Endoscopic Medicine, Mie University and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan; [email protected] (M.K.); [email protected] (K.T.); [email protected] (N.H.) 
 Digestive Endoscopy Center, Doshinkai Tohyama Hospital, Minami-Shinmachi 17-22, Tsu, Mie 514-0043, Japan; [email protected] 
 Department of Gastroenterology and Hepatology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan; [email protected] (Y.U.); [email protected] (H.M.); [email protected] (J.T.); [email protected] (R.Y.); [email protected] (M.N.); [email protected] (Y.H.); [email protected] (H.I.); [email protected] (Y.T.) 
 Department of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan; [email protected] 
First page
1779
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726694
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2547625666
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.