Full text

Turn on search term navigation

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 110 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.

Details

Title
Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus
Author
Yurchenko, Anton N 1   VIAFID ORCID Logo  ; Phan Thi Hoai Trinh 2   VIAFID ORCID Logo  ; Girich, Elena V 1 ; Smetanina, Olga F 1 ; Rasin, Anton B 1 ; Popov, Roman S 1 ; Dyshlovoy, Sergey A 3   VIAFID ORCID Logo  ; Gunhild von Amsberg 4 ; Menchinskaya, Ekaterina S 1 ; Tran Thi Thanh Van 2 ; Shamil Sh Afiyatullov 1 

 G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia[email protected] (O.F.S.); [email protected] (A.B.R.); [email protected] (R.S.P.); [email protected] (S.A.D.); [email protected] (E.S.M.); [email protected] (S.S.A.) 
 Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 650000 Nha Trang, Vietnam; [email protected] (P.T.H.T.); [email protected] (T.T.T.V.) 
 G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia[email protected] (O.F.S.); [email protected] (A.B.R.); [email protected] (R.S.P.); [email protected] (S.A.D.); [email protected] (E.S.M.); [email protected] (S.S.A.); School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia; Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; [email protected]; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany 
 Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; [email protected]; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany 
First page
579
Publication year
2019
Publication date
2019
Publisher
MDPI AG
e-ISSN
16603397
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2548654009
Copyright
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.