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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Brain metastases (BMs) are cancer cells that spread to the brain from primary tumors in other organs. Up to 35% of adult cancer patients develop BMs. The treatment of BM patients who have well-controlled extracranial disease and a small number of lesions consists of localized doses of radiation (stereotactic radio surgery (SRS)). Estimating prognosis among BM patients may allow treatments to be chosen that balance durability of intracranial tumor control with quality of life and the side effects of treatment. No mathematical model-based quantitative biomarkers have been determined for estimating prognosis. As a first step toward that goal, we describe a mathematical model of growth and response of brain metastasis to stereotactic radio surgery. The mathematical model incorporates some biological mechanisms involved in BM growth and response to SRS and allows the observed dynamics to be accurately described.

Details

Title
Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach
Author
León-Triana, Odelaisy 1   VIAFID ORCID Logo  ; Pérez-Beteta, Julián 1   VIAFID ORCID Logo  ; Albillo, David 2   VIAFID ORCID Logo  ; Ortiz de Mendivil, Ana 3   VIAFID ORCID Logo  ; Pérez-Romasanta, Luis 4   VIAFID ORCID Logo  ; González-Del Portillo, Elisabet 4 ; Llorente, Manuel 5 ; Carballo, Natalia 5 ; Arana, Estanislao 6   VIAFID ORCID Logo  ; Pérez-García, Víctor M 1   VIAFID ORCID Logo 

 Mathematical Oncology Laboratory (MOLAB), Department of Mathematics and Instituto de Matemática Aplicada a la Ciencia y la Ingeniería, Universidad de Castilla-La Mancha, Avda. Camilo José Cela, 3, 13071 Ciudad Real, Spain; [email protected] (J.P.-B.); [email protected] (V.M.P.-G.) 
 Radiology Unit, MD Anderson Cancer Center, 28033 Madrid, Spain; [email protected] 
 Department of Radiation Oncology, Sanchinarro University Hospital, HM Hospitales, 28015 Madrid, Spain; [email protected] 
 Radiation Oncology Service, Salamanca University Hospital, 37007 Salamanca, Spain; [email protected] (L.P.-R.); [email protected] (E.G.-D.P.) 
 MD Anderson Cancer Center, 28033 Madrid, Spain; [email protected] (M.L.); [email protected] (N.C.) 
 Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain; [email protected] 
First page
716
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
22277390
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2548817327
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.