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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

We report here the synthesis, characterization, and antibacterial evaluation of transition metal complexes of Ni, Cu, Co, Mn, Zn, and Cd (6af), using a Schiff base ligand (5) derived from naproxen (an anti-inflammatory drug) and 5-bromosalicylaldehyde by a series of reactions. The ligand and the synthesized complexes were characterized by elemental analysis, UV-Visible, FTIR, and XRD techniques. The ligand 5 behaves as a bidentate donor and coordinates with metals in square planar or tetrahedral fashion. In order to evaluate its bioactivity profile, we screened the Schiff base ligand and its metal complexes (6af) against different species of bacteria and the complexes were found to exhibit significant antibacterial activity. The complexes showed more potency against Bacillus subtilis as compared to the other species. Moreover, we modeled these complexes’ binding affinity against COX1 protein using computational docking.

Details

Title
Metal-Based Scaffolds of Schiff Bases Derived from Naproxen: Synthesis, Antibacterial Activities, and Molecular Docking Studies
Author
Muhammad Ashraf Shaheen 1   VIAFID ORCID Logo  ; Feng, Shanshan 2 ; Mehwish Anthony 3 ; Muhammad Nawaz Tahir 4 ; Mubashir Hassan 5 ; Sung-Yum Seo 5 ; Ahmad, Saeed 6 ; Iqbal, Mudassir 7   VIAFID ORCID Logo  ; Saleem, Muhammad 8   VIAFID ORCID Logo  ; Lu, Changrui 2 

 Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan 
 Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China 
 Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan 
 Department of Physics, University of Sargodha, Sargodha 40100, Pakistan 
 Collage of Natural science, Department of Biology, Kongju National University, Gongju, Chungcheongnam 32588, Korea 
 Department of Chemistry, College of Sciences and Humanities Prince Sattam bin Abdul Aziz University, Al-Kharj 11942, Saudi Arabia 
 Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences & Technology (NUST), H-12, Islamabad 44000, Pakistan 
 Department of Chemistry, University of Sargodha, Sub-campus, Bhakkar 30000, Pakistan 
First page
1237
Publication year
2019
Publication date
2019
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2548967062
Copyright
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.