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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Uniform Nd3+-doped LuVO4 nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd3+ and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pH medium and high cell viability. Because of these properties, the developed Nd3+-doped LuVO4 nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography.

Details

Title
Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging
Author
Nuñez, Nuria O 1 ; Cussó, Fernando 2 ; Cantelar, Eugenio 2   VIAFID ORCID Logo  ; Martin-Gracia, Beatriz 3 ; Jesús M de la Fuente 3   VIAFID ORCID Logo  ; Corral, Ariadna 4 ; Balcerzyk, Marcin 5   VIAFID ORCID Logo  ; Ocaña, Manuel 1   VIAFID ORCID Logo 

 Instituto de Ciencia de Materiales de Sevilla, CSIC-US, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain; [email protected] 
 Departamento de Física de Materiales, C-04, Universidad Autónoma de Madrid, 28049 Madrid, Spain; [email protected] (F.C.); [email protected] (E.C.) 
 Instituto de Ciencia de Materiales de Aragón, CSIC/UniZar and CIBER-BBN, Edificio I+D, Mariano Esquillor s/n, 50018 Zaragoza, Spain; [email protected] (B.M.-G.); [email protected] (J.M.d.l.F.) 
 Centro Nacional de Aceleradores (CNA) (Universidad de Sevilla, Junta de Andalucía, CSIC), c/Thomas Alva Edison 7, Isla de la Cartuja, 41092 Sevilla, Spain; [email protected] (A.C.); [email protected] (M.B.) 
 Centro Nacional de Aceleradores (CNA) (Universidad de Sevilla, Junta de Andalucía, CSIC), c/Thomas Alva Edison 7, Isla de la Cartuja, 41092 Sevilla, Spain; [email protected] (A.C.); [email protected] (M.B.); Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Calle San Fernando, 4, 41004 Sevilla, Spain 
First page
149
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20794991
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2548968039
Copyright
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.