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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The early diagnosis of pulmonary arterial hypertension (PAH) is a major determinant of prognosis in patients affected by connective tissue diseases (CTDs) complicated by PAH. In the present paper we investigated the diagnostic accuracy of cardiopulmonary exercise testing (CPET) in this specific setting. We recorded clinical and laboratory data of 131 patients who underwent a CPET at a pulmonary hypertension clinic. Out of them, 112 (85.5%) had a diagnosis of CTDs; 8 (6.1%) received a diagnosis of CTDs-PAH and 11 (8.4%) were affected PH of different etiology. Among CPET parameters the following parameters showed the best diagnostic performance for PAH: peak volume of oxygen uptake (VO2; AUC: 0.845, CI95% 0.767–0.904), ratio between ventilation and volume of exhaled carbon dioxide (VE/VCO2 slope; AUC: 0.888, CI95%: 0.817–0.938) and end-tidal partial pressures (PetCO2; AUC: 0.792, CI95%: 0.709–0.861). These parameters were comparable among CTDs-PAH and PH of different etiology. The diagnostic performance was even improved by creating a composite score which included all the three parameters identified. In conclusion, CPET is a very promising tool for the stratification of risk of PAH among CTDs patients; the use of composite measures may improve diagnostic performance.

Details

Title
Cardiopulmonary Exercise Testing Is an Accurate Tool for the Diagnosis of Pulmonary Arterial Hypertension in Scleroderma Related Diseases
Author
Bellan, Mattia 1   VIAFID ORCID Logo  ; Giubertoni, Ailia 2 ; Piccinino, Cristina 3 ; Buffa, Mariachiara 4 ; Cromi, Debora 4 ; Sola, Daniele 3 ; Pedrazzoli, Roberta 3 ; Gagliardi, Ileana 4 ; Calzaducca, Elisa 4 ; Zecca, Erika 4 ; Patrucco, Filippo 2   VIAFID ORCID Logo  ; Patti, Giuseppe 2 ; Sainaghi, Pier Paolo 1   VIAFID ORCID Logo  ; Pirisi, Mario 1 

 Department of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy; [email protected] (A.G.); [email protected] (M.B.); [email protected] (D.C.); [email protected] (I.G.); [email protected] (E.C.); [email protected] (E.Z.); [email protected] (F.P.); [email protected] (G.P.); [email protected] (P.P.S.); [email protected] (M.P.); “AOU Maggiore della Carità” Hospital, 28100 Novara, Italy; [email protected] (C.P.); [email protected] (D.S.); [email protected] (R.P.); CAAD, (Center for Translational Research on Autoimmune and Allergic Disease) Maggiore della Carità Hospital and Università del Piemonte Orientale UPO, 28100 Novara, Italy 
 Department of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy; [email protected] (A.G.); [email protected] (M.B.); [email protected] (D.C.); [email protected] (I.G.); [email protected] (E.C.); [email protected] (E.Z.); [email protected] (F.P.); [email protected] (G.P.); [email protected] (P.P.S.); [email protected] (M.P.); “AOU Maggiore della Carità” Hospital, 28100 Novara, Italy; [email protected] (C.P.); [email protected] (D.S.); [email protected] (R.P.) 
 “AOU Maggiore della Carità” Hospital, 28100 Novara, Italy; [email protected] (C.P.); [email protected] (D.S.); [email protected] (R.P.) 
 Department of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy; [email protected] (A.G.); [email protected] (M.B.); [email protected] (D.C.); [email protected] (I.G.); [email protected] (E.C.); [email protected] (E.Z.); [email protected] (F.P.); [email protected] (G.P.); [email protected] (P.P.S.); [email protected] (M.P.) 
First page
342
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
14248247
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2550211509
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.