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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) and shockwave (SW) therapy have been shown to exert a chondroprotective effect for osteoarthritis (OA). The results of this study demonstrated that autologous ADSCs had dose-dependent and synergistic effects with SW therapy (0.25 mJ/mm2 with 800 impulses) in OA rat knee joint. Autologous, high-dose 2 × 106 ADSCs (ADSC2 group) combined with SW therapy significantly increased the bone volume, trabecular thickness, and trabecular number among in the treatment groups. ADSC2 combined with SW therapy significantly reduced the synovitis score and OARSI score in comparison with other treatments. In the analysis of inflammation-induced extracellular matrix factors of the articular cartilage in OA, the results displayed that ADSC2 combined with SW therapy had a greater than other treatments in terms of reducing tumor necrosis factor-inducible gene (TSG)-6 and proteoglycan (PRG)-4, in addition to increasing tissue inhibitor matrix metalloproteinase (TIMP)-1 and type II collagen. Furthermore, ADSC2 combined with SW therapy significantly reduced the expression of inflammation-induced bone morphogenetic protein (BMP)-2 and BMP-6. Therefore, the results demonstrated that ADSC2 combined with SW therapy had a synergistic effect to ameliorate osteoarthritic pathological factors in OA joints.

Details

Title
Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint
Author
Jai-Hong, Cheng 1   VIAFID ORCID Logo  ; Ke-Tien Yen 2 ; Wen-Yi, Chou 3 ; Shun-Wun Jhan 3 ; Shan-Ling Hsu 4 ; Jih-Yang, Ko 3 ; Wang, Ching-Jen 3 ; Chun-En, Aurea Kuo 5   VIAFID ORCID Logo  ; Wu, Szu-Ying 5 ; Tsai-Chin, Hsu 3 ; Chieh-Cheng Hsu 3   VIAFID ORCID Logo 

 Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; [email protected] (W.-Y.C.); [email protected] (S.-W.J.); [email protected] (S.-L.H.); [email protected] (J.-Y.K.); [email protected] (C.-J.W.); [email protected] (T.-C.H.); Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; Department of Leisure and Sports Management, Cheng Shiu University, Kaohsiung 833, Taiwan; [email protected] 
 Department of Leisure and Sports Management, Cheng Shiu University, Kaohsiung 833, Taiwan; [email protected] 
 Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; [email protected] (W.-Y.C.); [email protected] (S.-W.J.); [email protected] (S.-L.H.); [email protected] (J.-Y.K.); [email protected] (C.-J.W.); [email protected] (T.-C.H.); Department of Orthopedic Surgery, Sports Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan 
 Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; [email protected] (W.-Y.C.); [email protected] (S.-W.J.); [email protected] (S.-L.H.); [email protected] (J.-Y.K.); [email protected] (C.-J.W.); [email protected] (T.-C.H.); Department of Orthopedic Surgery, Sports Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; School of Nursing, Fooyin University, Kaohsiung 831, Taiwan 
 Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan; [email protected] (C.-E.A.K.); [email protected] (S.-Y.W.) 
First page
318
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
14248247
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2550211560
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.