It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effects of different interventions. We conducted a study using the Taiwan National Health Insurance Research Database. The IDA cohort consisted of 13,381 patients with newly diagnosed IDA between 2000 and 2008. Each patient with IDA was frequency-matched with one people without IDA, by sex, age and index year. The Cox proportional hazards regression analysis was conducted to estimate the association between IDA and FM risk. The event was the occurrence of FM. The overall incidence density rate of FM in the IDA cohort was higher than in the non-IDA cohort with a multivariable Cox proportional hazards model measured adjusted hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.13–1.25). When using non-IDA group as reference, we compared with different therapies for IDA. The adjusted HRs of FM were 1.38 (95% CI = 1.30–1.47), 1.10 (95% CI = 1.03–1.16), 1.18 (95% CI = 0.98–1.43) and 0.73 (95% CI = 0.58–0.90) for IDA patient without therapy, iron supplement alone, blood transfusion alone and both iron supplement and blood transfusion respectively. Our results suggest IDA is associated with an increased risk of FM. All patients should have iron supplementation both to correct anemia and replenish body stores.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Min-Sheng General Hospital, Department of Anesthesiology and Pain Medicine, Taoyuan City, Taiwan (GRID:grid.415675.4) (ISNI:0000 0004 0572 8359)
2 China Medical University, College of Medicine, Taichung City, Taiwan (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092); Management Office for Health Data, China Medical University Hospital, Taichung City, Taiwan (GRID:grid.411508.9) (ISNI:0000 0004 0572 9415)
3 Mackay Medical College, Department of Medicine, New Taipei City, Taiwan (GRID:grid.452449.a) (ISNI:0000 0004 1762 5613); MacKay Memorial Hospital, Department of Laboratory Medicine, Taipei City, Taiwan (GRID:grid.413593.9) (ISNI:0000 0004 0573 007X)
4 Mackay Memorial Hospital, Division of Infectious Diseases, Department of Internal Medicine, Taipei, Taiwan (GRID:grid.413593.9) (ISNI:0000 0004 0573 007X); MacKay Junior College of Medicine, Nursing and Management, Department of Cosmetic Applications and Management, New Taipei City, Taiwan (GRID:grid.507991.3) (ISNI:0000 0004 0639 3191)
5 Taichung Veterans General Hospital, Healthcare Service Research Center (HSRC), Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731)
6 Mackay Medical College, Department of Medicine, New Taipei City, Taiwan (GRID:grid.452449.a) (ISNI:0000 0004 1762 5613); MacKay Memorial Hospital, Department of Laboratory Medicine, Taipei City, Taiwan (GRID:grid.413593.9) (ISNI:0000 0004 0573 007X); Mackay Medical College, Graduate Institute of Biomedical Sciences; Graduate Institute of Long-Term Care, New Taipei City, Taiwan (GRID:grid.452449.a) (ISNI:0000 0004 1762 5613); Johns Hopkins University, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA (GRID:grid.21107.35) (ISNI:0000 0001 2171 9311)