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Abstract
The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different anatomical subsites in the Taiwanese population. We retrospectively analyzed data for 3010 patients with OSCC treated at the Changhua Christian Hospital. Subsequently, we compared clinical and pathological features of OSCC in different subsites. Pathological T4 stage OSCCs occurred in the alveolar ridge and retromolar trigone in 56.4% and 43.7% of cases, respectively. More than 25% of patients with tongue OSCC and 23.4% of those with retromolar OSCC had lymph node metastasis. The prognosis was worst for hard palate OSCC (hazard ratio 1.848; p < 0.001) and alveolar ridge OSCC (hazard ratio 1.220; p = 0.017). Retromolar OSCC recurred most often and tongue OSCC second most often. The risk for cancer-related mortality was highest for hard palate OSCC, followed by alveolar ridge and retromolar OSCC. We found distinct differences in survival among the different subsites of OSCC. Our findings may also help prompt future investigations of OSCC in different subsites in Taiwanese patients.
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1 China Medical University, School of Dentistry, Taichung, Taiwan (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092); Changhua Christian Hospital, Department of Oral and Maxillofacial Surgery, Changhua, Taiwan (GRID:grid.413814.b) (ISNI:0000 0004 0572 7372); Show Chwan Memorial Hospital, Department of Oral and Maxillofacial Surgery, Changhua, Taiwan (GRID:grid.452796.b) (ISNI:0000 0004 0634 3637)
2 Changhua Christian Hospital, Department of Oral and Maxillofacial Surgery, Changhua, Taiwan (GRID:grid.413814.b) (ISNI:0000 0004 0572 7372)
3 China Medical University, School of Dentistry, Taichung, Taiwan (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092); Asia University, Department of Bioinformatics and Medical Engineering, Taichung, Taiwan (GRID:grid.252470.6) (ISNI:0000 0000 9263 9645)
4 China Medical University, School of Dentistry, Taichung, Taiwan (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092); China Medical University Hospital, Dental Department and Division of Oral Maxillofacial Surgery, Taichung, Taiwan (GRID:grid.411508.9) (ISNI:0000 0004 0572 9415)