Abstract

Characterized by multiple complex mutations, including activation by oncogenes and inhibition by tumor suppressors, cancer is one of the leading causes of death. Application of CRISPR-Cas9 gene-editing technology in cancer research has aroused great interest, promoting the exploration of the molecular mechanism of cancer progression and development of precise therapy. CRISPR-Cas9 gene-editing technology provides a solid basis for identifying driver and passenger mutations in cancer genomes, which is of great value in genetic screening and for developing cancer models and treatments. This article reviews the current applications of CRISPR-Cas9 gene-editing technology in various cancer studies, the challenges faced, and the existing solutions, highlighting the potential of this technology for cancer treatment.

Details

Title
Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
Author
Zhao, Ziyi; Li, Chenxi; Tong, Fei; Deng, Jingkuang; Huang, Guofu; Yi, Sang
Pages
1-13
Section
Review
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
14809222
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2557848986
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.