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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Besides the well-known functions performed by vitamin B12 (CblCN) in biochemical processes of the human body, an increasing interest has been raised by the possibility of its use as a transmembrane drug carrier, capable, among others, of enhancing the accumulation of inorganic cytostatics in cancer cells. The present study was aimed at determining the possibility of the formation of CblCN conjugates with Pd(II) complexes. A key aspect was their stability, which we attempted to tune by appropriate choice of ligands. Syntheses, spectroscopic analysis of postreaction systems and kinetic investigations of conjugate formation reactions, have been complemented by DFT modelling. The obtained results showed that ligand charge, geometry and electron affinity may have a significant impact on carrier binding and release leading to the activation of the Pd(II) complex. This provides a rationale to expect that with appropriate composition of the coordination sphere, it will be possible to extend the spectrum of less toxic inorganic chemotherapeutics.

Details

Title
Ligand-Tuning of the Stability of Pd(II) Conjugates with Cyanocobalamin
Author
Porębska, Dominika 1   VIAFID ORCID Logo  ; Orzeł, Łukasz 1 ; Rutkowska-Zbik, Dorota 2 ; Stochel, Grażyna 1 ; Rudi van Eldik 3   VIAFID ORCID Logo 

 Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland; [email protected] (D.P.); [email protected] (G.S.) 
 Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, Poland; [email protected] 
 Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland; [email protected] (D.P.); [email protected] (G.S.); Department of Chemistry and Pharmacy, University Erlangen-Nuremberg, Egerlandstr 1, 91058 Erlangen, Germany 
First page
7973
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2558836208
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.